Cell Mol Biol Lett:黄酮类化合物可抑制脂多糖诱导的心肌炎症

2017-09-13 MedSci MedSci原创

与感染性心内膜炎中严重炎症反应相关的牙菌斑微生物之一是牙龈卟啉单胞菌。它是慢性牙周炎患者的一种革兰氏阴性细菌。牙龈卟啉单胞菌脂多糖(LPS)可促进白介素-1(IL-1),IL-6和肿瘤坏死因子α(TNF-α)的表达。黄酮类物质被认为参与控制炎症的过程,如环氧合酶-2(COX-2)的表达。研究人员调查了木犀草素,槲皮素,染料木素和栎草亭对单独使用LPS或与以下抑制剂p38(SB203580),ERK

感染性心内膜炎中严重炎症反应相关的牙菌斑微生物之一是牙龈卟啉单胞菌。它是慢性牙周炎患者的一种革兰氏阴性细菌。牙龈卟啉单胞菌脂多糖(LPS)可促进白介素-1(IL-1),IL-6和肿瘤坏死因子α(TNF-α)的表达。黄酮类物质被认为参与控制炎症的过程,如环氧合酶-2(COX-2)的表达。

研究人员调查了木犀草素,槲皮素,染料木素和栎草亭对单独使用LPS或与以下抑制剂p38(SB203580),ERK(PD98059),JNK(SP600125)和PKC(Calphostin C)组合治疗1小时的心肌细胞的影响。在基因和蛋白质水平上测定激酶活化和COX-2表达水平。

结果显示,这些黄酮类化合物被认为抑制丝裂原活化蛋白激酶(MAPK)的激活和κB-α(IκB-α)抑制剂的降解。它们也在COX-2表达中起作用。

总之,该研究结果表明,黄酮类化合物可抑制LPS在H9c2细胞中诱导的炎症反应。

原始出处:


Gloria Gutiérrez-Venegas, Alfredo Torras-Ceballos,et al., Luteolin, quercetin, genistein and quercetagetin inhibit the effects of lipopolysaccharide obtained from Porphyromonas gingivalis in H9c2 cardiomyoblasts. Cell Mol Biol Lett. 2017; 22: 19. Published online 2017 Sep 4. doi: 10.1186/s11658-017-0047-z

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    2018-08-11 fengyi821
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    2018-05-24 维他命
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createdName=维他命, createdTime=Thu May 24 18:05:00 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767219, encodeId=56591e6721927, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Fri Jan 26 15:05:00 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953963, encodeId=de4e195396313, content=<a href='/topic/show?id=eb4c1032145f' target=_blank style='color:#2F92EE;'>#黄酮类化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103214, 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href='/topic/show?id=cc2584301d4' target=_blank style='color:#2F92EE;'>#脂多糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84301, encryptionId=cc2584301d4, topicName=脂多糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f354234967, createdName=小刀医生, createdTime=Fri Sep 15 07:05:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243873, encodeId=cc1e2438e325, content=文章很好.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 14 09:42:28 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243698, encodeId=1d90243698fa, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Sep 13 23:42:34 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
  5. 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href='/topic/show?id=cc2584301d4' target=_blank style='color:#2F92EE;'>#脂多糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84301, encryptionId=cc2584301d4, topicName=脂多糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f354234967, createdName=小刀医生, createdTime=Fri Sep 15 07:05:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243873, encodeId=cc1e2438e325, content=文章很好.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 14 09:42:28 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243698, encodeId=1d90243698fa, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Sep 13 23:42:34 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-12-05 sunylz
  6. 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  7. 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  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243698, encodeId=1d90243698fa, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed Sep 13 23:42:34 CST 2017, time=2017-09-13, status=1, ipAttribution=)]
    2017-09-14 1e10c84am36(暂无匿称)

    文章很好.值得分享

    0

  10. 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    2017-09-13 184****9840

    学习了谢谢分享

    0

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