Gynecol Oncol:调强放疗(IMRT)可以提高子宫内膜癌淋巴结复发的生存时间

2015-10-24 candy 译 MedSci原创

目标:盆腔及腹主动脉旁区域是没有接受辅助放疗的子宫内膜癌患者淋巴结复发的最频繁部位。我们调查了子宫内膜癌后淋巴结复发的患者,进行增强放射治疗(IMRT)后的生存结局。方法:在2002年-2012年间,38名子宫内膜癌后盆腔及腹主动脉旁淋巴结复发的病人使用了IMRT疗法,她们从未接受过外束辐射治疗。13例(34%)曾在IMRT前接受放疗,21例(55%)仅接受同期放疗。盆腔淋巴结通常使用45至50G

目标:盆腔及腹主动脉旁区域是没有接受辅助放疗的子宫内膜癌患者淋巴结复发的最频繁部位。我们调查了子宫内膜癌后淋巴结复发的患者,进行调强放疗(IMRT)后的生存结局。

方法:在2002年-2012年间,38名子宫内膜癌后盆腔及腹主动脉旁淋巴结复发的病人使用了IMRT疗法,她们从未接受过外束辐射治疗。13例(34%)曾在IMRT前接受放疗,21例(55%)仅接受同期放疗。盆腔淋巴结通常使用45至50Gy的辐射量,因能作用于总肿瘤的总中位数为64.7 Gy(范围59-73 Gy)。

结果:总中位生存时间为46.1个月,2年生存率为71%。接受同期放疗的病人较未接受此治疗病人有显著增长的生存中位时间(61.9个月VS28.7个月,P=0.034)。在接受放疗前曾接受过化疗的病人更容易在治疗过程中发生不良反应,同时他们的肿瘤分级也更高,使用的放射剂量更少。3例(8%)在治疗过程中发生3-4级的晚期胃肠道毒性(GI)事件。

结论:淋巴结转移的子宫内膜癌患者可以达到更长的生存时间。同步化疗与剂量递增的放疗可以有效提高子宫内膜癌后孤立淋巴结复发的生存时间。

原始出处:


Ho JC, Allen PK, et al.Management of nodal recurrences of endometrial cancer with IMRT.Gynecol Oncol. 2015 Oct;139(1):40-6. 


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    2016-02-09 minlingfeng
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    2015-11-01 DrYCheng

    应该翻译成 调强放疗…

    0

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    2015-10-26 sodoo