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Eur J Oral Implantol：慢性牙周炎和种植体周围炎骨保护素（OPG）基因多态性分析

2018-02-08 MedSci MedSci原创

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核因子κB配体（RANKL）/RANK/OPG通路的受体激活剂在破骨细胞生成、破骨细胞活化和骨吸收的调节中发挥重要作用。近来，单核苷酸多态性（SNP）已经被报道为炎性疾病发病机制中的辅助因子。本研究旨在探讨骨保护素（OPG）基因多态性与伊朗人群中慢性牙周炎和种植体周围炎的关系。 研究纳入了慢性牙周炎（CP）77例，种植体周围炎（PI）40例，牙周健康者89例。从参与者的手臂静脉获得总共5ml的血液

核因子κB配体（RANKL）/RANK/OPG通路的受体激活剂在破骨细胞生成、破骨细胞活化和骨吸收的调节中发挥重要作用。近来，单核苷酸多态性（SNP）已经被报道为炎性疾病发病机制中的辅助因子。本研究旨在探讨骨保护素（OPG）基因多态性与伊朗人群中慢性牙周炎和种植体周围炎的关系。

研究纳入了慢性牙周炎（CP）77例，种植体周围炎（PI）40例，牙周健康者89例。从参与者的手臂静脉获得总共5ml的血液。基于盐析方法提取DNA。用聚合酶链式反应和限制性片段长度多态性（PCR_RFLP）分析两个功能性SNP（T950C和G1181C）。采用卡方检验计算三个批次的患病率差异。

结果显示，对T950C基因型的评估发现组间无统计学差异。种植体周围炎和慢性牙周炎组之间以及种植体周围炎组与正常组之间的G1181C基因型分布比较发现，种植体周围炎患者的CC基因型频率显着高于对照组（P = 0.005）。

综上所述，该研究结果表明，G1181C的SNP与PI的存在有关。

原始出处：

Kadkhodazadeh M, Tabari ZA, et al., Analysis of osteoprotegerin (OPG) gene polymorphism in Iranian patients with chronic periodontitis and peri-implantitis. A cross-sectional study. Eur J Oral Implantol. 2012 Winter;5(4):381-8.

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    2018-09-14 小几洁

    #Oral#

    0

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    2018-08-28 xuyu

    #plant#

    0

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    2018-04-17 huangdf

    #种植#

    0

  4. 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02:55:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368641, encodeId=d7231368641e2, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Sat Feb 10 02:55:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450760, encodeId=f2871450e60ea, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, 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    2018-05-03 xuyong536

    #MPL#

    0

  5. 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    2018-02-10 ms6279672939590805

    #种植体#

    0

  6. 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02:55:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368641, encodeId=d7231368641e2, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Sat Feb 10 02:55:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450760, encodeId=f2871450e60ea, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, 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    2018-02-10 piaojinhua

    #慢性牙周炎#

    0

  7. 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    2018-02-10 liuyong2982

    #牙周#

    0

  8. 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    2018-02-10 xzw120

    #多态性#

    0

  9. 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    2018-02-09 沙漠浪人

    基因多态性与伊朗人群中慢性牙周炎和种植体周围炎

    0