FASEB J:研究发现白色脂肪向棕色脂肪转换的化学物质

2016-10-16 MedSci MedSci原创

近日,据发表于FASEB J的一项新的研究表明,通过雌激素受体β(ERβ)激活一种称为Beta-LGND2的化学物质,可将“坏”脂肪(白色脂肪)转换成“好”脂肪(棕色脂肪),从而可改善小鼠肥胖和代谢疾病。棕色脂肪可增加代谢,并可能有助于减肥。研究人员设置了三组小鼠,其中一组喂食正常饮食,而其余两组给予高脂饮食(HFD)从而使小鼠肥胖。其中一组高脂喂养组小鼠使用赋形剂处理,而另一组高脂喂养组小鼠接受

近日,据发表于FASEB J的一项新的研究表明,通过雌激素受体β(ERβ)激活一种称为Beta-LGND2的化学物质,可将“坏”脂肪(白色脂肪)转换成“好”脂肪(棕色脂肪),从而可改善小鼠肥胖和代谢疾病。棕色脂肪可增加代谢,并可能有助于减肥。

研究人员设置了三组小鼠,其中一组喂食正常饮食,而其余两组给予高脂饮食(HFD)从而使小鼠肥胖。其中一组高脂喂养组小鼠使用赋形剂处理,而另一组高脂喂养组小鼠接受Beta-LGND2处理。

结果发现,与其他接受高脂饮食的小鼠相比,接受Beta-LGND2处理的小鼠明显偏瘦。Beta-LGND2组小鼠的身体温度和氧耗量较高,表明这些小鼠的代谢率较高。

代谢综合征和肥胖威胁着世界各地的数百万人的健康,此研究或为这些疾病的治疗提供一个有益的药理学治疗前景。

原始出处:

New molecule may help fight obesity by converting 'bad' fat to 'good' fat. Science Daily, October 14, 2016.

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    2017-06-11 gracezdd
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createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-17 深海的鱼

    转化

    0

  5. 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createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-17 圣艮山

    终于显示出来了

    0

  6. 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createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-16 1e1487afm65(暂无匿称)

    这是一个热点

    0

  7. 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createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-16 lietome1

    学习了,赞一个!

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161013/IMG57FF1AB36A79C3246.jpg, createdBy=b0911965225, createdName=1e1487afm65(暂无匿称), createdTime=Sun Oct 16 23:43:08 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148849, encodeId=0c41148849d9, content=学习了,赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Sun Oct 16 18:46:54 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148838, encodeId=d479148838a8, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0df71676643, createdName=1de2495dm19(暂无匿称), createdTime=Sun Oct 16 17:34:47 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148813, encodeId=89741488137a, content=现在这种物质很多呀,为什么这么多人关注这点, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Sun Oct 16 14:26:29 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148810, encodeId=2cab148810e9, content=好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-16 1de2495dm19(暂无匿称)

    继续学习

    0

  9. 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createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-16 圣艮山

    现在这种物质很多呀,为什么这么多人关注这点

    0

  10. 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createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-16 1def5ef1m18(暂无匿称)

    好!

    0