ATVB:新研究证明颈动脉硬化与静脉血栓栓塞无关

2013-11-07 高晓方 译 医学论坛网

既往研究显示动静脉血栓栓塞有相同的危险因素,但近期挪威一项研究表明,颈动脉粥样硬化与未来心梗具有显著相关性,但与静脉血栓栓塞(VTE)无关。论文10月31日在线发表于《动脉硬化、血栓形成与血管生物学》(ATVB)。 此项研究共纳入6257例年龄为25~84岁的受试者,并利用超声测定了右颈动脉平均内中膜厚度和总体斑块面积。登记随访期间的事件性心梗和VTE。利用以年龄为时标的Cox比例风险回顾模

既往研究显示动静脉血栓栓塞有相同的危险因素,但近期挪威一项研究表明,颈动脉粥样硬化与未来心梗具有显著相关性,但与静脉血栓栓塞(VTE)无关。论文10月31日在线发表于《动脉硬化、血栓形成与血管生物学》(ATVB)。


此项研究共纳入6257例年龄为25~84岁的受试者,并利用超声测定了右颈动脉平均内中膜厚度和总体斑块面积。登记随访期间的事件性心梗和VTE。利用以年龄为时标的Cox比例风险回顾模型,评估随内中膜厚度和总体斑块面积增加的心梗和VTE归因危险比。

结果显示,中位随访15.4年间共发生894和256起心梗和VTE事件。平均内中膜厚度四分位数组的心梗风险均显著增加(P趋势<0.001),总体斑块面积增加时心梗风险亦显著升高(P趋势<0.001)。然而,在多变量校正分析中,内中膜厚度和总体斑块面积均与VTE风险无相关性。


原文出处:

Hald EM, Lijfering WM, Mathiesen EB, Johnsen SH, Løchen ML, Njølstad I, Wilsgaard T, Rosendaal FR, Brækkan SK, Hansen JB.Carotid Atherosclerosis Predicts Future Myocardial Infarction But Not Venous Thromboembolism: The Tromso Study.Arterioscler Thromb Vasc Biol. 2013 Oct 31. 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2026446, encodeId=120c2026446e0, content=<a href='/topic/show?id=fea8100558be' target=_blank style='color:#2F92EE;'>#颈动脉硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100558, encryptionId=fea8100558be, topicName=颈动脉硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Tue Mar 04 23:52:00 CST 2014, time=2014-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843374, encodeId=124718433e47c, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sun Dec 22 05:52:00 CST 2013, time=2013-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697184, encodeId=ffe5169e184bf, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Fri Sep 19 03:52:00 CST 2014, time=2014-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977930, encodeId=a8a419e793067, content=<a href='/topic/show?id=20411e958de' target=_blank style='color:#2F92EE;'>#TVB#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17958, encryptionId=20411e958de, topicName=TVB)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Wed Sep 10 08:52:00 CST 2014, time=2014-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955191, encodeId=6f3d1955191c2, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Tue Jun 17 19:52:00 CST 2014, time=2014-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6275, encodeId=f15b62e5ea, content=可以理解。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f1286833, createdName=sence, createdTime=Wed Nov 13 02:56:00 CST 2013, time=2013-11-13, status=1, ipAttribution=)]
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    2014-09-19 fusion
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    2014-09-10 gongliu
  5. [GetPortalCommentsPageByObjectIdResponse(id=2026446, encodeId=120c2026446e0, content=<a href='/topic/show?id=fea8100558be' target=_blank style='color:#2F92EE;'>#颈动脉硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100558, encryptionId=fea8100558be, topicName=颈动脉硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Tue Mar 04 23:52:00 CST 2014, time=2014-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843374, encodeId=124718433e47c, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sun Dec 22 05:52:00 CST 2013, time=2013-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697184, encodeId=ffe5169e184bf, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Fri Sep 19 03:52:00 CST 2014, time=2014-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977930, encodeId=a8a419e793067, content=<a href='/topic/show?id=20411e958de' target=_blank style='color:#2F92EE;'>#TVB#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17958, encryptionId=20411e958de, topicName=TVB)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Wed Sep 10 08:52:00 CST 2014, time=2014-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955191, encodeId=6f3d1955191c2, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Tue Jun 17 19:52:00 CST 2014, time=2014-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6275, encodeId=f15b62e5ea, content=可以理解。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f1286833, createdName=sence, createdTime=Wed Nov 13 02:56:00 CST 2013, time=2013-11-13, status=1, ipAttribution=)]
    2014-06-17 xue8602
  6. [GetPortalCommentsPageByObjectIdResponse(id=2026446, encodeId=120c2026446e0, content=<a href='/topic/show?id=fea8100558be' target=_blank style='color:#2F92EE;'>#颈动脉硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100558, encryptionId=fea8100558be, topicName=颈动脉硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Tue Mar 04 23:52:00 CST 2014, time=2014-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843374, encodeId=124718433e47c, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sun Dec 22 05:52:00 CST 2013, time=2013-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697184, encodeId=ffe5169e184bf, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Fri Sep 19 03:52:00 CST 2014, time=2014-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977930, encodeId=a8a419e793067, content=<a href='/topic/show?id=20411e958de' target=_blank style='color:#2F92EE;'>#TVB#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17958, encryptionId=20411e958de, topicName=TVB)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Wed Sep 10 08:52:00 CST 2014, time=2014-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955191, encodeId=6f3d1955191c2, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Tue Jun 17 19:52:00 CST 2014, time=2014-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6275, encodeId=f15b62e5ea, content=可以理解。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f1286833, createdName=sence, createdTime=Wed Nov 13 02:56:00 CST 2013, time=2013-11-13, status=1, ipAttribution=)]
    2013-11-13 sence

    可以理解。

    0

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