Gut:粪便中潜血与全因和非结直肠癌死亡率相关

2018-07-18 xing.T MedSci原创

由此可见,可检测到的f-Hb与多种原因引起的死亡风险增加有关。

据报道,可检测的粪便血红蛋白(f-Hb)与结直肠癌(CRC)死亡风险和全因死亡率之间存在关联。近日,消化病领域权威杂志Gut上发表了一篇研究文章,研究人员开始在英国人群中证实或反驳这一观察性结果,并探讨组织粪便潜血试验(gFOBT)阳性结果f-Hb与不同原因死亡之间的关联。

研究人员通过将在2000年3月29日至2016年3月29日期间参与苏格兰泰赛德进行gFOBT筛查的所有受试者(134192)的测试结果(阳性或阴性)与苏格兰国家记录数据库的死亡率数据联系起来,并随访至2016年3月30日。

研究人员发现具有阳性检测结果(n=2714)的受试者死亡风险高于检测结果为阴性的患者:死于CRC:HR为7.79(95%CI为6.13-9.89),p<0.0001(调整了性别、年龄和可能导致出血的药物)以及所有非CRC原因:HR为1.58(95%CI为1.45-1.73),p<0.0001。此外,gFOBT可检测到的f-Hb与死于循环系统疾病、呼吸系统疾病、消化系统疾病(不包括CRC)、神经心理疾病、血液和内分泌疾病以及非CRC疾病的风险增加显著相关。

由此可见,可检测到的f-Hb与多种原因引起的死亡风险增加有关。

原始出处:

Gillian Libby.et al. Occult blood in faeces is associated with all-cause and non-colorectal cancer mortality.Gut. 2018. http://dx.doi.org/10.1136/gutjnl-2018-316483

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