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J Dent Res：牙周组织损伤骨愈合过程中骨质疏松的改变

2019-01-26 MedSci MedSci原创

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骨质疏松症与骨密度降低和骨脆性增加有关，但这种疾病如何影响牙槽骨愈合尚不清楚。本研究旨在确定骨质疏松症对颌骨骨骼的影响程度，然后评估骨质疏松表型可能影响拔牙后牙槽骨愈合速率的可能机制。使用卵巢切除小鼠模型结合微型计算机断层扫描成像，组织学，分子和细胞测定，我们首先证明了附肢和颌骨骨骼都发展为骨质疏松症表型。接下来，我们证明骨质疏松小鼠表现出牙周韧带（PDL）的萎缩，并且这种萎缩伴随着PDL中骨祖细

骨质疏松症与骨密度降低和骨脆性增加有关，但这种疾病如何影响牙槽骨愈合尚不清楚。本研究旨在确定骨质疏松症对颌骨骨骼的影响程度，然后评估骨质疏松表型可能影响拔牙后牙槽骨愈合速率的可能机制。

使用卵巢切除小鼠模型结合微型计算机断层扫描成像，组织学，分子和细胞测定，我们首先证明了附肢和颌骨骨骼都发展为骨质疏松症表型。接下来，我们证明骨质疏松小鼠表现出牙周韧带（PDL）的萎缩，并且这种萎缩伴随着PDL中骨祖细胞池的减少。 PDL衍生的骨祖细胞在骨质疏松小鼠中的缺乏与显着较慢的拔牙窝愈合相关。

总的来说，这些分析表明颌骨骨骼容易受到骨质疏松症的不良影响，这些影响表现为更薄，更多孔的牙槽骨，PDL变薄和更慢的骨修复。这些发现对于接受重建手术的老年骨质减少患者具有潜在的临床意义。

原始出处：

Arioka M, Zhang X, et al., Osteoporotic Changes in the Periodontium Impair Alveolar Bone Healing. J Dent Res. 2019 Jan 9:22034518818456. doi: 10.1177/0022034518818456.

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    2019-09-01 redcrab

    #骨愈合#

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    2019-06-23 shock_melon

    #牙周组织#

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    2019-01-28 ms3046638856685384

    #损伤#

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    2019-01-28 医者仁心

    #牙周#

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    2019-01-28 Eleven17

    #骨质#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2026987, encodeId=c28b202698e80, content=<a href='/topic/show?id=921d101668c8' target=_blank style='color:#2F92EE;'>#骨愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101668, encryptionId=921d101668c8, topicName=骨愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Sun Sep 01 04:03:00 CST 2019, time=2019-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969715, encodeId=0eca1969e1500, content=<a href='/topic/show?id=641e6e5300d' target=_blank style='color:#2F92EE;'>#牙周组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67530, encryptionId=641e6e5300d, topicName=牙周组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58df296, createdName=shock_melon, createdTime=Sun Jun 23 13:03:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397706, encodeId=ca9c139e706e1, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Mon Jan 28 07:03:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451103, encodeId=daf91451103c0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Jan 28 07:03:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592538, encodeId=c23f1592538cb, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Mon Jan 28 07:03:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688803, encodeId=c0c41688803e7, content=<a href='/topic/show?id=8667e769859' target=_blank style='color:#2F92EE;'>#组织损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77698, encryptionId=8667e769859, topicName=组织损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c7fe28645771, createdName=小几洁, createdTime=Tue Feb 26 21:03:00 CST 2019, time=2019-02-26, status=1, ipAttribution=)]
    2019-02-26 小几洁

    #组织损伤#

    0