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Lancet：骨斑点症-案例报道

2016-05-09 Mechront 译 MedSci原创

骨斑点症遗传转移
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患者男，17岁，泌尿外科手术后伤口感染5天。CT评估感染深度时显示：骨盆和股骨近端可见局限、卵圆形、不透x线的骨病变。诊断：骨斑点症。该疾病为常染色体显性遗传性疾病，十分罕见，数据显示，发病率不到1/1000万。以硬化的骨病变最常累及手、脚、骨盆和长骨的两端为疾病主要特点，患者可无任何临床症状，常常是通过影像学检查偶然发现该疾病。如何区分骨斑点症和骨转移性疾病？骨斑点症常常不会有骨破坏，病变对称分

患者男，17岁，泌尿外科手术后伤口感染5天。

CT评估感染深度时显示：骨盆和股骨近端可见局限、卵圆形、不透x线的骨病变。



诊断：骨斑点症。

该疾病为常染色体显性遗传性疾病，十分罕见，数据显示，发病率不到1/1000万。以硬化的骨病变最常累及手、脚、骨盆和长骨的两端为疾病主要特点，患者可无任何临床症状，常常是通过影像学检查偶然发现该疾病。

如何区分骨斑点症和骨转移性疾病？骨斑点症常常不会有骨破坏，病变对称分布，好发部位也和骨转移性疾病不同，骨转移性疾病常见于椎体、肋骨和长骨骨干等。此外，骨斑点症患者的骨显像结果不会有异常。

目前该疾病还不需要日常随访或研究。

原始出处：

Amara Ogbonnaya,Brittany Middleton,et al.Osteopoikilosis.The Lancet.DOI: http://dx.doi.org/10.1016/S0140-6736(13)60674-1

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    2016-12-21 howi

    #Lancet#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1828475, encodeId=906618284e502, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Dec 21 04:56:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129470, encodeId=7b941294e0e3, content=不错哦，会学到很多，喜欢梅斯医学文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Sep 17 11:52:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108706, encodeId=2da2108e06c7, content=好文，值得学习，赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 01 08:47:00 CST 2016, time=2016-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106890, encodeId=782610689004, content=深入学习，好文值得点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Aug 29 14:32:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85860, encodeId=ded78586026, content=骨斑点症，第一次听说，才疏学浅，惭愧。, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Sun May 15 11:09:00 CST 2016, time=2016-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85687, encodeId=3bf48568e5e, content=我去年也遇到了一例, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160423/IMG571B6B2B5167E6436.jpg, createdBy=14f51715663, createdName=WEIXINef251673, createdTime=Sat May 14 06:41:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85330, encodeId=b7078533046, content=值得阅读，学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Tue May 10 12:50:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85068, encodeId=dc6485068dc, content=值得阅读！, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Mon May 09 16:21:00 CST 2016, time=2016-05-09, status=1, ipAttribution=)]
    2016-09-17 1e10c84am36(暂无匿称)

    不错哦，会学到很多，喜欢梅斯医学文章

    0

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    2016-09-01 ylzr123

    好文，值得学习，赞！

    0

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    2016-08-29 ylzr123

    深入学习，好文值得点赞！

    0

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    2016-05-15 Lisa971

    骨斑点症，第一次听说，才疏学浅，惭愧。

    0

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    2016-05-14 WEIXINef251673

    我去年也遇到了一例

    0

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    2016-05-10 1dd8a7c5m95(暂无匿称)

    值得阅读，学习！

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1828475, encodeId=906618284e502, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Dec 21 04:56:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129470, encodeId=7b941294e0e3, content=不错哦，会学到很多，喜欢梅斯医学文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Sep 17 11:52:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108706, encodeId=2da2108e06c7, content=好文，值得学习，赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 01 08:47:00 CST 2016, time=2016-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106890, encodeId=782610689004, content=深入学习，好文值得点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Aug 29 14:32:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85860, encodeId=ded78586026, content=骨斑点症，第一次听说，才疏学浅，惭愧。, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Sun May 15 11:09:00 CST 2016, time=2016-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85687, encodeId=3bf48568e5e, content=我去年也遇到了一例, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160423/IMG571B6B2B5167E6436.jpg, createdBy=14f51715663, createdName=WEIXINef251673, createdTime=Sat May 14 06:41:00 CST 2016, time=2016-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85330, encodeId=b7078533046, content=值得阅读，学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Tue May 10 12:50:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85068, encodeId=dc6485068dc, content=值得阅读！, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Mon May 09 16:21:00 CST 2016, time=2016-05-09, status=1, ipAttribution=)]
    2016-05-09 jaysppr

    值得阅读！

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