外周血HER2基因扩增检测(数字PCR法)在抗HER2治疗中的应用共识

2022-01-27 复旦大学附属肿瘤医院 中国癌症杂志

乳腺癌患者中20%~30%人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)阳性,该类型乳腺癌具有恶性程度高、侵袭性强、预后差等特点。

中文标题:

外周血HER2基因扩增检测(数字PCR法)在抗HER2治疗中的应用共识

发布日期:

2022-01-27

简要介绍:

乳腺癌患者中20%~30%人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)阳性,该类型乳腺癌具有恶性程度高、侵袭性强、预后差等特点。抗HER2靶向药物能有效地降低HER2阳性乳腺癌患者复发和转移的风险,延长生存期,改善预后,HER2状态是乳腺癌重要的预后评估指标和抗HER2治疗选择的主要预测指标。众多国内外指南和共识均推荐可获取肿瘤组织的乳腺癌患者采用免疫组织化学法(immunohistochemistry,IHC)检测HER2受体蛋白的水平,采用荧光原位杂交法(fluorescence in situ hybridization,FISH)检测HER2基因的扩增水平。 

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    2022-03-20 ms8000002023252547

    0

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    2022-02-13 ms3000000637975859

    非常好

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