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The RNA demethylase ALKBH5 promotes osteoblast differentiation by modulating Runx2 mRNA stability

期刊: FEBS LETTERS, 2021; 595 (15)

AlkB homolog 5 (ALKBH5) has been reported as a key m6A demethylase that is involved in development and diseases; however, the function of ALKBH5 in os......

hnRNPA1 enhances FOXP3 stability to promote the differentiation and functions of regulatory T cells

期刊: FEBS LETTERS, 2021; 595 (14)

Regulatory T cells (Tregs) are indispensable for the maintenance of immunological self-tolerance and homeostasis. Heterogeneous nuclear ribonucleoprot......

Proteolysis of gamma-tubulin small complex proteins is mediated by the ubiquitin-proteasome system

期刊: FEBS LETTERS, 2021; 595 (15)

Microtubule nucleation is mainly mediated by the gamma-tubulin ring complex (gamma TuRC), whose core components are gamma-tubulin and gamma-tubulin co......

Periostin deficiency attenuates lipopolysaccharide- and obesity-induced adipose tissue fibrosis

期刊: FEBS LETTERS, 2021; 595 (16)

Periostin (POSTN) is a type of matricellular protein, but its functions in adipose fibrosis remain unclear. Here, we found that POSTN expression is si......

Class A G protein-coupled receptors assemble into functional higher-order hetero-oligomers

期刊: FEBS LETTERS, 2021; 595 (14)

Although class A seven-transmembrane helix (7TM) receptor hetero-oligomers have been proposed, information on the assembly and function of such higher......

The SLIM1 transcription factor is required for arsenic resistance in Arabidopsis thaliana

期刊: FEBS LETTERS, 2021; 595 (12)

The transcriptional regulators of arsenic-induced gene expression remain largely unknown. Sulfur assimilation is tightly linked with arsenic detoxific......

Serum levels of the IgA isotype switch factor TGF-beta 1 are elevated in patients with COVID-19

期刊: FEBS LETTERS, 2021; 595 (13)

We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID-19, which might confer damaging effects. Given the important role of ......

Phosphorylation of the conserved C-terminal domain of ribosomal P-proteins impairs the mode of interaction with plant toxins

期刊: FEBS LETTERS, 2021; 595 (17)

The ribosome is subjected to post-translational modifications, including phosphorylation, that affect its biological activity. Among ribosomal element......

Human SND2 mediates ER targeting of GPI-anchored proteins with low hydrophobic GPI attachment signals

期刊: FEBS LETTERS, 2021; 595 (11)

Over 100 glycosylphosphatidylinositol-anchored proteins (GPI-APs) are encoded in the mammalian genome. It is not well understood how these proteins ar......

Genome-wide analysis of the mouse LIM gene family reveals its roles in regulating pathological cardiac hypertrophy

期刊: FEBS LETTERS, 2021; 595 (17)

LIM-domain proteins have been shown to be associated with heart development and diseases. Systematic studies of LIM family members at the genome-wide ......

Generation and characterization of a high-affinity chimeric anti-OX40 antibody with potent antitumor activity

期刊: FEBS LETTERS, 2021; 595 (11)

OX40 is a costimulatory molecule that belongs to the tumor necrosis factor receptor (TNFR) superfamily. OX40 agonist-based combinations are emerging a......

Absence of CG methylation alters the long noncoding transcriptome landscape in multiple species

期刊: FEBS LETTERS, 2021; 595 (12)

The noncoding regions throughout the genome are in large part comprised of transposable elements (TEs), some of which are functionalized with long int......

Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression

期刊: FEBS LETTERS, 2021; 595 (16)

Human coilin-interacting nuclear ATPase protein (hCINAP), also known as adenylate kinase 6 (AK6), is an atypical adenylate kinase with critical roles ......

Siglec-15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD44

期刊: FEBS LETTERS, 2021; 595 (17)

Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) has been identified as a novel potential target for cancer immunotherapy. Here, we explo......

Elf4 regulates lysosomal biogenesis and the mTOR pathway to promote clearance of Staphylococcus aureus in macrophages

期刊: FEBS LETTERS, ; ()

Staphylococcus aureus is a major cause of infectious disease. Macrophages can directly destroy most of the invading bacteria through the phagolysosoma......

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