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Elucidating the Morphogenic and Signaling Roles of Defined Growth Factors Controlling Human Endothelial Cell Lumen Formation Versus Sprouting Behavior

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (12)

Five growth factors [ie, insulin, fibroblast growth factor-2 (FGF-2), stem cell factor, IL-3, and stromalderived factor 1a] in combination are necessa......

Differential Diagnosis of Hematologic and Solid Tumors Using Targeted Transcriptome and Artificial Intelligence

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (1)

Diagnosis and classification of tumors is increasingly dependent on biomarkers. RNA expression profiling using next-generation sequencing provides rel......

FUT8-AS1/miR-944/Fused in Sarcoma/Transcription Factor 4 Feedback Loop Participates in the Development of Oral Squamous Cell Carcinoma through Activation of Wnt/b-Catenin Signaling Pathway

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (2)

As a common type of head and neck squamous cell carcinoma, oral squamous cell carcinoma (OSCC) is a lethal and deforming disease. Long noncoding RNAs ......

RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (10)

Lung adenocarcinoma (LUAD) is a common subtype of primary lung cancer. Fatty acid oxidation plays a key role in LUAD development by providing energy f......

Mitochondria and Endoplasmic Reticulum Stress in Retinal Organoids from Patients with Vision Loss

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (11)

Activating transcription factor 6 (ATF6), a key regulator of the unfolded protein response, plays a key role in endoplasmic reticulum function and pro......

Standardized Classification of Lung Adenocarcinoma Subtypes and Improvement of Grading Assessment Through Deep Learning

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (12)

The histopathologic distinction of lung adenocarcinoma (LADC) subtypes is subject to high interobserver variability, which can compromise the optimal ......

The Effects of Hyperglycemia on Early Endothelial Activation and the Initiation of Atherosclerosis

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (1)

It is well established that patients with diabetes have an increased risk of developing atherosclerotic cardiovascular disease. The earliest detectabl......

Metabolome Sequencing Reveals that Protein Arginine-N-Methyltransferase 1 Promotes the Progression of Invasive Micropapillary Carcinoma of the Breast and Predicts a Poor Prognosis

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (9)

Invasive micropapillary carcinoma (IMPC) of the breast is a special histopathologic type of cancer with a high recurrence rate and the biological feat......

The Role of Gut Microbiome-Derived Short-Chain Fatty Acid Butyrate in Hepatobiliary Diseases

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (10)

The short-chain fatty acid butyrate, produced from fermentable carbohydrates by gut microbiota in the colon, has multiple beneficial effects on human ......

Tumor Mutation Burden-Related Histopathologic Features for Predicting Overall Survival in Gliomas Using Graph Deep Learning

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (12)

Tumor mutation burden (TMB) is a potential biomarker for evaluating the prognosis and response to immune checkpoint inhibitors, but its costly and tim......

Genomic Characterization of Prostatic Basal Cell Carcinoma

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (1)

Basal cell carcinoma (BCC) of the prostate is a rare tumor. Compared with the more common acinar adenocarcinoma (AAC) of the prostate, BCCs show featu......

Genome-Wide Analysis of Hypoxia-Inducible Factor Binding Reveals Targets Implicated in Impaired Human Placental Syncytiotrophoblast Formation under Low Oxygen

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (7)

Preeclampsia (PE) is a common and serious complication of pregnancy with no cure except premature delivery. The root cause of PE is improper developme......

The Microbiome, Ocular Surface, and Corneal Disorders

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (11)

The ocular surface microbiome is an emerging field of study that seeks to understand how the com-munity of microorganisms found on the ocular surface ......

Adolescence and the Microbiome Implications for Healthy Growth and Maturation

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2023; 193 (12)

The gut microbiota was initially thought to develop into a stable, adult-like profile during early postnatal life. The formation of the gut microbiota......

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