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Investigating the relevance of CYP2J2 inhibition for drugs known to cause intermediate to high risk torsades de pointes

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 187 ()

Cardiac cytochrome P450 2J2 (CYP2J2) metabolizes endogenous polyunsaturated fatty acid, arachidonic acid (AA), to bioactive regioisomeric epoxyeicosat......

Candesartan exhibits low intrinsic permeation capacity and affects buccal tissue viability and integrity: An ex vivo study in porcine buccal mucosa

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 188 ()

Candesartan is a nonpeptide angiotensin II receptor blocker that selectively binds to angiotensin II receptor subtype 1. It is administered orally in ......

Managing the clinical effects of drug-induced intestinal dysbiosis with a focus to antibiotics: Challenges and opportunities

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 188 ()

The term intestinal dysbiosis is used for indicating change(s) of the intestinal microbiota which have been associated with the development of disease......

Dissolution changes in drug-amino acid/biotin co-amorphous systems: Decreased/increased dissolution during storage without recrystallization

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 188 ()

Co-amorphous systems have been proven to be a promising strategy to address the poor water solubility of poorly water-soluble drugs. Generally, the in......

A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 189 ()

pH-responsive hydrogels have become effective and attractive materials for the controlled release of drugs at pre-determined destinations. In the pres......

Micro-lightguide spectrophotometry assessment of hepatic and intestinal microcirculation in endotoxemic rats during intravenous treatment with angiotensin II

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 191 ()

Introduction: During septic shock, impairment of microcirculation leads to enhanced permeability of intestinal mucosa triggered by generalized vasodil......

Advancing algorithmic drug product development: Recommendations for machine learning approaches in drug formulation

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 191 ()

Artificial intelligence is a rapidly expanding area of research, with the disruptive potential to transform traditional approaches in the pharmaceutic......

Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 183 ()

Valproic acid (VPA) is a short-chain fatty acid widely prescribed in the treatment of seizure disorders and epi-lepsy syndromes, although its therapeu......

Pharmacokinetics, safety, and efficacy of GM1 ganglioside in healthy subjects and patients with multiple myeloma: Two dose-escalation studies

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 190 ()

Purpose: This study aimed to assess the pharmacokinetics, safety, and efficacy of GM1 in healthy Chinese subjects and patients with multiple myeloma.M......

Development of a thermosensitive hydrogel based on Polaxamer 407 and gellan gum with inclusion complexes (Sulfobutylated-β-cyclodextrin-Farnesol) as a local drug delivery system

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 191 ()

This work proposes the development of a thermosensitive local drug release system based on Polaxamer 407, also known as Pluronic (R) F-127 (PF-127), G......

Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 185 ()

Phosphodiesterase 4 (PDE4) inhibitors have been extensively researched for their anti-inflammatory and neuroregenerative properties. Despite the known......

The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 187 ()

ABS T R A C T The purpose of this review is to summarize the current knowledge on three physiological determinants of oral drug absorption, i.e., gast......

Immune cell extravasation in an organ-on-chip to model lung inflammation

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 187 ()

Acute respiratory distress syndrome (ARDS) is a severe lung condition with high mortality and various causes, including lung infection. No specific tr......

Advancements, challenges and future perspectives on peptide-based drugs: Focus on antimicrobial peptides

期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023; 181 ()

Among other health related issues, the rising concerns on drug resistance led to look for alternative pharmaceutical drugs that are effective both aga......

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