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Intra-Exon Motif Correlations as a Proxy Measure for Mean Per-Tile Sequence Quality Data in RNA-Seq

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 30 (2)

Given the wide variability in the quality of next-generation sequencing data submitted to public repositories, it is essential to identify methods tha......

IntOMICS: A Bayesian Framework for Reconstructing Regulatory Networks Using Multi-Omics Data

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 0 (0)

Integration of multi-omics data can provide a more complex view of the biological system consisting of different interconnected molecular components. ......

Gene Deletion Algorithms for Minimum Reaction Network Design by Mixed-Integer Linear Programming for Metabolite Production in Constraint-Based Models: gDel_minRN

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 30 (5)

Genome-scale constraint-based metabolic networks play an important role in the simulation of growth-coupled production, which means that cell growth a......

Speeding Up the Structural Analysis of Metabolic Network Models Using the Fredman-Khachiyan Algorithm B

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 30 (6)

The problem of computing the Elementary Flux Modes (EFMs) and Minimal Cut Sets (MCSs) of metabolic network is a fundamental one in metabolic networks.......

Inferring Optimal Species Trees in the Presence of Gene Duplication and Loss: Beyond Rooted Gene Trees

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 30 (2)

Estimating species trees from multiple genes is complicated and challenging due to gene tree-species tree discordance. One of the basic approaches to ......

Generalization of Phylogenetic Matching Metrics with Experimental Tests of Practical Advantages

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 30 (3)

The ability to quantify a dissimilarity of different phylogenetic trees is required in various types of phylogenetic studies, for example, such metric......

MAMMLE: A Framework for Phylogeny Estimation Based on Multiobjective Application-aware Multiple Sequence Alignment and Maximum Likelihood Ensemble

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 30 (3)

Motivation: Phylogenetic trees are often inferred from a multiple sequence alignment (MSA) where the tree accuracy is heavily impacted by the nature o......

On the Convexity of the Effective Reproduction Number

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 30 (7)

In this study, we analyze the evolution of the effective reproduction number, R, through a Susceptible-Infective-Recovered spreading process in hetero......

Constructing Double Cyclic Codes over F2+uF2 for DNA Codes

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 1 (1)

In this article, we investigate the algebraic structure of double cyclic codes of length (alpha,beta) over F-2+uF(2) with u(2)=0 and construct DNA cod......

pyBrick-DNA: A Python-Based Environment for Automated Genetic Component Assembly

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 30 (12)

Genetic component assembly is key in the simulation and implementation of genetic circuits. Automating this process, thus accelerating prototyping, is......

A Fixed-Parameter Tractable Algorithm for Finding Agreement Cherry-Reduced Subnetworks in Level-1 Orchard Networks

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; ()

Phylogenetic networks are increasingly being considered better suited to represent the complexity of the evolutionary relationships between species. O......

ClassGraph: Improving Metagenomic Read Classification with Overlap Graphs

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 30 (6)

Current technologies allow the sequencing of microbial communities directly from the environment without prior culturing. One of the major problems wh......

Efficient Colored de Bruijn Graph for Indexing Reads

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 30 (6)

The colored de Bruijn graph is a variation of the de Bruijn graph that has recently been utilized for indexing sequencing reads. Although state-of-the......

The Reasoning Engine: A Satisfiability Modulo Theories-Based Framework for Reasoning About Discrete Biological Models

期刊: JOURNAL OF COMPUTATIONAL BIOLOGY, 2023; 30 (9)

We present a framework called the Reasoning Engine, which implements Satisfiability Modulo Theories (SMT)-based methods within a unified computational......

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