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Effects of more natural housing conditions on the muscular and skeletal characteristics of female C57BL/6J mice

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

BackgroundEnrichment of home cages in laboratory experiments offers clear advantages, but has been criticized in some respects. First, there is a lack......

Exploration of the anti-diabetic potential of hydro-ethanolic leaf extract of Koenigia polystachya L.: an edible wild plant from Northeastern India

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

Background: Globally, medicinal plants are used to treat diseases like diabetes. The present study evaluates the possible antioxidant, acute oral toxi......

Feline mammary carcinoma-derived extracellular vesicle promotes liver metastasis via sphingosine kinase-1-mediated premetastatic niche formation

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

BackgroundFeline mammary carcinoma (FMC) is one of the most prevalent malignancies of female cats. FMC is highly metastatic and thus leads to poor dis......

Regenerative medicine owes to microsurgery

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

New findings in regenerative medicine have always been combined with numerous animal studies. Therefore, choosing the right translational animal model......

Effects of isoflurane and xylazine on inducing cerebral ischemia by the model of middle cerebral artery occlusion in mice

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

Preclinical ischemic stroke studies extensively utilize the intraluminal suture method of middle cerebral artery occlusion (MCAo). General anesthesia ......

Shikimic acid recovers diarrhea and its complications in SD rats fed lactose diet to induce diarrhea

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

BackgroundDiarrhea is the increase of excretion of human water content and an imbalance in the physiologic processes of the small and large intestine ......

Staphylococcus xylosus and Staphylococcus aureus as commensals and pathogens on murine skin

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

Skin ulcers, skin dermatitis and skin infections are common phenomena in colonies of laboratory mice and are often found at increased prevalence in ce......

Compositional changes in fecal microbiota in a new Parkinson's disease model: C57BL/6-Tg(NSE-haSyn) mice

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

Background The gut-brain axis (GBA) in Parkinson's disease (PD) has only been investigated in limited mice models despite dysbiosis of the gut microbi......

Sheep as a large animal model for hearing research: comparison to common laboratory animals and humans

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

Sensorineural hearing loss (SNHL), caused by pathology in the cochlea, is the most common type of hearing loss in humans. It is generally irreversible......

Datura metel stramonium exacerbates behavioral deficits, medial prefrontal cortex, and hippocampal neurotoxicity in mice via redox imbalance

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

Background Datura metel (DM) stramonium is a medicinal plant often abused by Nigerians due to its psychostimulatory properties. Hallucinations, confus......

Epigallocatechin gallate restores the reduction of protein phosphatase 2 A subunit B caused by middle cerebral artery occlusion

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

BackgroundEpigallocatechin gallate (EGCG) is a flavonoid compound commonly found in green tea. It exhibits antioxidant, anti-inflammatory, and neuropr......

Comparison of immunophenotypes between Rag2 knockout mice derived from two different sources

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

Background Recombination activating gene2 (Rag2) knockout (KO) mice are used widely in various research fields, including vaccine development, transpl......

Case report on successful treatment for brain abscess in a Japanese monkey (Macaca fuscata)

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

BackgroundA brain abscess in human beings is a focal infection of the central nervous system frequently characterized by areas of localized cerebritis......

A case study assessing the impact of mating frequency on the reproductive performance of the Hawaiian bobtail squid Euprymna scolopes

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

BackgroundThe symbiosis between the Hawaiian bobtail squid Euprymna scolopes and bacterium Vibrio fischeri serves as a model for investigating the mol......

Regular medical checkup program (in K-MEDI hub) to enhance the welfare of laboratory dogs and pigs

期刊: LABORATORY ANIMAL RESEARCH, 2023; 39 (1)

BackgroundThe importance of animal welfare is being recognized worldwide. Recently, the increasing demand for enhanced laboratory animal welfare has l......

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