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Recent progress and structural analyses of domain-selective BET inhibitors

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (4)

Epigenetic mechanisms for controlling gene expression through heritable modifications to DNA, RNA, and proteins, are essential processes in maintainin......

Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (6)

The high incidence of oral cancer combined with excessive treatment cost underscores the need for novel oral cancer preventive and therapeutic options......

Molecular mechanism(s) of regulations of cancer stem cell in brain cancer propagation

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (3)

Brain tumors are most often diagnosed with solid neoplasms and are the primary reason for cancer-related deaths in both children and adults worldwide.......

Molecular mechanisms and therapeutic perspectives of peroxisome proliferator-activated receptor α agonists in cardiovascular health and disease

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (6)

The prevalence of cardiovascular disease (CVD) has been rising due to sedentary lifestyles and unhealthy dietary patterns. Peroxisome proliferator-act......

Key characters of glycodrugs

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (4)

Glycodrug is an important chemical medicine category derived from biological carbohydrates and their mimics. However, the fundamental logic and featur......

Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (6)

The blood platelet plays an important role but often remains under-recognized in several vascular complications and associated diseases. Surprisingly,......

Histone deacetylase-based dual targeted inhibition in multiple myeloma

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (6)

Despite enormous advances in terms of therapeutic strategies, multiple myeloma (MM) still remains an incurable disease with MM patients often becoming......

Bacterial proton motive force as an unprecedented target to control antimicrobial resistance

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (4)

Novel antibacterial therapies are urgently required to tackle the increasing number of multidrug-resistant pathogens. Identification of new antimicrob......

A comprehensive and systemic review of ginseng-based nanomaterials: Synthesis, targeted delivery, and biomedical applications

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (5)

Among 17 Panax species identified across the world, Panax ginseng (Korean ginseng), Panax quinquefolius (American ginseng), and Panax notoginseng (Chi......

Targeting epigenetic modifications in Parkinson's disease therapy

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (5)

Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between genetic and epigenetic factors. Recent efforts shed new light ......

Profiling of small-molecule necroptosis inhibitors based on the subpockets of kinase-ligand interactions

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (6)

Necroptosis is a highly regulated cell death (RCD) form in various inflammatory diseases. Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 are ......

Glutathione-triggered prodrugs: Design strategies, potential applications, and perspectives

期刊: MEDICINAL RESEARCH REVIEWS, 2023; ()

The burgeoning prodrug strategy offers a promising avenue toward improving the efficacy and specificity of cytotoxic drugs. Elevated intracellular lev......

Human mpox: Biology, epidemiology, therapeutic options, and development of small molecule inhibitors

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (4)

Although monkeypox (mpox) has been endemic in Western and Central Africa for 50 years, it has not received sufficient prophylactic and therapeutical a......

Parkin exerts the tumor-suppressive effect through targeting mitochondria

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (4)

The role of PARKIN in Parkinson's disease is well established but its role in cancer has recently emerged. PARKIN serves as a tumor suppressor in many......

Use of baricitinib in treatment of COVID-19: a systematic review

期刊: MEDICINAL RESEARCH REVIEWS, 2023; 43 (5)

ObjectiveTo assess the role of baricitinib alone or in combination with other therapies as a treatment for patients with COVID-19. MethodsSystematic l......

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