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Tannic acid may ameliorate doxorubicin-induced changes in oxidative stress parameters in rat spleen

期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2023; ()

Doxorubicin (DOX) is a potent and broad-spectrum drug widely used in the treatment of cancer. However, the toxicity and side effects of DOX on various......

Ergometrine stimulates histamine H2 receptors in the isolated human atrium

期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2023; ()

Ergometrine (6aR,9R)-N-((S)-1-hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9-hexa-hydro-indolo-[4,3-fg]chinolin-9-carboxamide or lysergide acid beta-ethano......

Cardioprotective effect of naringin against the ischemia/reperfusion injury of aged rats

期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2023; ()

Aging is known as a main risk factor in the development of cardiovascular diseases. Naringin (NRG) is a flavonoid compound derived from citrus fruits.......

The monoaminergic pathways are involved in the antidepressant-like effect of quercetin

期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2023; ()

Quercetin, a plant-derived flavonoid, is an antioxidant and has demonstrated antidepressant and anti-inflammatory activities in several animal models.......

Effects of natural products on functional constipation: analysis of active ingredient and mechanism

期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2023; ()

Constipation is a prevalent clinical ailment of the gastrointestinal system, yet its pathogenesis remains ambiguous. Despite the availability of numer......

Single versus intermittent cycle exposure effect of 6-mercaptopurine in juvenile Sprague-Dawley rat: a germ cell-specific mechanistic study

期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2023; ()

Infertility is a frequent long-term adverse effect of cancer therapy for children. Compromised testicular functions in adolescence are frequent observ......

Unraveling the rationale and conducting a comprehensive assessment of KD025 (Belumosudil) as a candidate drug for inhibiting adipogenic differentiation-a systematic review

期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2023; ()

Rho-associated kinases (ROCKs) are crucial during the adipocyte differentiation process. KD025 (Belumosudil) is a newly developed inhibitor that selec......

Antibiofilm activity of mesoporous silica nanoparticles against the biofilm associated infections

期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2023; ()

In pharmaceutical industries, various chemical carriers are present which are used for drug delivery to the correct target sites. The most popular and......

Leflunomide abrogates neuroinflammatory changes in a rat model of Alzheimer's disease: the role of TNF-α/NF-κB/IL-1β axis inhibition

期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2023; 396 (3)

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and is associated with disrupted cognition and behavior. Neuroinflammato......

Expression of ER stress markers (GRP78 and PERK) in experimental nephrotoxicity induced by cisplatin and gentamicin: roles of inflammatory response and oxidative stress

期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2023; 396 (4)

This study aimed to establish the relationship between two endoplasmic reticulum (ER) stress proteins, glucose-regulated protein 78 (GRP78/BiP) and PK......

Pulmonary inflammation, oxidative stress, and fibrosis in a mouse model of cholestasis: the potential protective properties of the dipeptide carnosine

期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2023; 396 (6)

Cholestasis is a clinical complication that primarily influences the liver. However, it is well known that many other organs could be affected by chol......

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