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Methylmercury drives lipid droplet formation and adipokine expression during the late stages of adipocyte differentiation in 3T3-L1 cells

期刊: TOXICOLOGY, 2023; 486 ()

Chronic exposure to methylmercury (MeHg) is positively associated with obesity and metabolic syndromes. However, the effect of MeHg on adipogenesis ha......

Toxicity mechanism of peri-implantation pesticide beta-cypermethrin exposure on endometrial remodeling in early pregnant mice

期刊: TOXICOLOGY, 2023; 489 ()

Beta-cypermethrin (beta-CYP) is a universally used pyrethroid pesticide with adverse effects on human health. beta-CYP may impair endometrial remodeli......

Dibutyl phthalate induces epithelial-mesenchymal transition of renal tubular epithelial cells via the Ang II/AMPKα2/Cx43 signaling pathway

期刊: TOXICOLOGY, 2023; 494 ()

Maternal exposure to dibutyl phthalate (DBP) induces renal fibrosis in offspring. However, the specific roles of connexin 43 (Cx43) in DBP-induced ren......

Hexabromocyclododecane (HBCD) induced PANoptosis of chondrocytes via activation of the NLRP3 inflammasome and decreased the exercise ability of mice in vivo

期刊: TOXICOLOGY, 2023; 499 ()

Hexabromocyclododecane (HBCD) is a persistent organic pollutant (POP). HBCD is found in the blood and tissues of most populations and causes a range o......

Clinical and experimental research progress on neurotoxicity of sulfur mustard and its possible mechanisms

期刊: TOXICOLOGY, 2023; 483 ()

Sulfur mustard (SM), an extremely reactive alkylating toxicant, which poses a continuing threat to both military and civilian populations. SM targets ......

Di-(2-ethylhexyl) phthalate aggravates fine particulate matter-induced asthma in weanling mice due to T follicular helper cell-dependent response

期刊: TOXICOLOGY, 2023; 484 ()

Environmental pollutants fine particulate matter and di-(2-ethylhexyl) phthalate (DEHP) are believed to be the risk factors for childhood asthma. Alle......

Cobalt chloride exposure disturbs spindle assembly and decreases mouse oocyte development potential

期刊: TOXICOLOGY, 2023; 486 ()

Cobalt is a kind of heavy metal which is widely used in petrochemical and biomedical industries. Animal studies have reported that cobalt would exert ......

An integrated in silico-in vitro investigation to assess the skin sensitization potential of 4-Octylphenol

期刊: TOXICOLOGY, 2023; 493 ()

One of the major challenges in chemical toxicity testing is the possibility to protect human health against adverse effects with non-animal methods. I......

Multi-omics analyses of serum metabolome, urine metabolome and gut microbiome reveal dysregulated glycerophospholipid metabolism in subacute cadmium-exposed wistar rats

期刊: TOXICOLOGY, 2023; 494 ()

Data is limited on intestinal microbiota and metabolites in healthy residents exposed to cadmium (Cd), a population uniquely susceptible to Cd toxicit......

Molecular mechanism of the carboxyl terminus of Hsc70-interacting protein in TAU hyperphosphorylation induced by AlCl3 in N2a cells

期刊: TOXICOLOGY, 2023; 495 ()

Aluminum (Al) is recognized as a neurotoxin. Studies have confirmed that the neurotoxicity induced by Al may be related to tau hyperphosphorylation. P......

Exploring cardiac impact of oral nicotine exposure in a transplantable Neoplasm Mice Model: Insights from biochemical analysis, morphometry, and molecular docking: Chlorella vulgaris green algae support

期刊: TOXICOLOGY, 2023; 497 ()

Nicotine-induced cardiac tissue damage is a concern for cancer patients, but the exact pathogenesis from nicotine oral exposure is unclear. This study......

Bisphenol A induced neuronal apoptosis and enhanced autophagy in vitro through Nrf2/HO-1 and Akt/mTOR pathways

期刊: TOXICOLOGY, 2023; 500 ()

Bisphenol A (BPA) was traditionally used in epoxy resins and polycarbonate plastics, but it was found to be harmful to human health due to its endocri......

Embryotoxicity evaluation of Gentamicin, an aminoglycoside antibiotic added to human embryo culture medium, using the zebrafish (Danio rerio) model

期刊: TOXICOLOGY, 2023; 483 ()

Infertility gives rise to a lot of social and psychological problems. At present, assisted reproductive technology (ART) is an important way to solve ......

Disruption of the lung-gut-brain axis is responsible for cortex damage induced by pulmonary exposure to zinc oxide nanoparticles

期刊: TOXICOLOGY, 2023; 485 ()

Increasing evidence shows that gut microbiota is important for host health in response to metal nanomaterials exposure. However, the effect of gut mic......

Baicalin alleviates bleomycin-induced early pulmonary fibrosis in mice via the mitoKATP signaling pathway

期刊: TOXICOLOGY, 2023; 497 ()

Bleomycin (BLM), a frequently employed chemotherapeutic agent, exhibits restricted clinical utility owing to its pulmonary toxicity. Meanwhile, baical......

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