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Development of dominant epitope-based vaccines encoding Gp63, Kmp-11 and Amastin against visceral leishmaniasis

期刊: IMMUNOBIOLOGY, 2021; 226 (3)

The most dangerous form of leishmaniasis is Visceral leishmaniasis (VL). The elimination of VL depends not only on agent treatments but also on effect......

The level of thymic stromal lymphopoietin and its gene polymorphism are associated with rheumatoid arthritis

期刊: IMMUNOBIOLOGY, 2021; 226 (2)

Objective: To study the correlation between TSLP gene SNPs and RA in a Han Chinese population. Methods: The genotypes of TSLP genes rs11466749, rs1146......

Effects of TNF-alpha on autophagy of rheumatoid arthritis fibroblast-like synoviocytes and regulation of the NF-kappa B signaling pathway

期刊: IMMUNOBIOLOGY, 2021; 226 (2)

Rheumatoid arthritis (RA) is a common chronic autoimmune disease, which seriously harms human health. The hyperplastic growth of fibroblast-like synov......

The role of NFAT2/miR-20a-5p signaling pathway in the regulation of CD8(+) naive T cells activation and differentiation

期刊: IMMUNOBIOLOGY, 2021; 226 (4)

T cell dysfunction is a common characteristic in leukemia patients that significantly impacts clinical treatment and prognosis. However, the mechanism......

Exposure of pregnant rats to staphylococcal enterotoxin B increases offspring splenic Treg number and function via decreasing FoxP3 methylation

期刊: IMMUNOBIOLOGY, 2021; 226 (2)

Staphylococcus aureus is an infectious pathogen that is relatively common, but that can cause severe disease in pregnant women and their fetus. We pre......

T-B cell epitope peptides induce protective immunity against Mycoplasma pneumoniae respiratory tract infection in BALB/c mice

期刊: IMMUNOBIOLOGY, 2021; 226 (3)

Mycoplasma pneumoniae is the most common pathogen of community-acquired pneumonia in humans. Due to its high rates of antibiotic resistance, vaccinati......

STC1 ameliorates cognitive impairment and neuroinflammation of Alzheimer's disease mice via inhibition of ERK1/2 pathway

期刊: IMMUNOBIOLOGY, 2021; 226 (3)

Objective: To investigate the regulatory role of STC1 (Stanniocalcin-1) mediated ERK1/2 pathway in cognitive impairment and neuroinflammation of Alzhe......

Effects of TRIM59 on RAW264.7 macrophage gene expression and function

期刊: IMMUNOBIOLOGY, 2021; 226 (4)

Macrophages have a variety of functions, such as secreting cytokines, phagocytosis, et al. Tripartite motif containing 59 (TRIM59) protein is highly e......

Advances in immunotherapy for the treatment of spinal cord injury

期刊: IMMUNOBIOLOGY, 2021; 226 (1)

Spinal cord injury (SCI) is a leading cause of morbidity and disability in the world. Over the past few decades, the exact molecular mechanisms descri......

The analysis of organization and diversity mechanism in goat immunoglobulin light chain gene loci

期刊: IMMUNOBIOLOGY, 2020; 225 (2)

The genomic organization of goat immunoglobulin light chains (Ig lambda and Ig kappa) loci were annotated based on the goat genome database. The goat ......

Discovering novel lung cancer associated antigens and the utilization of their autoantibodies in detection of lung cancer

期刊: IMMUNOBIOLOGY, 2020; 225 (2)

Objective: The identification of tumor-associated antigens (TAAs) and their corresponding autoantibodies in lung cancer (LC) may expand our vision of ......

Endoplasmic reticulum stress in autoimmune diseases

期刊: IMMUNOBIOLOGY, 2020; 225 (2)

If the body's immune system is disordered and begins to attack "self" and therefore, its own tissues this is considered to be an autoimmune pathology.......

Research progresses of molecular mechanism of pyroptosis and its related diseases

期刊: IMMUNOBIOLOGY, 2020; 225 (2)

Pyroptosis is a newly discovered untypical form of programmed cell death by inflammatory response, which is dependent on the classic pathway of Caspas......

Systemic sclerosis associated with moyamoya syndrome: A case report and literature review

期刊: IMMUNOBIOLOGY, 2020; 225 (2)

Systemic sclerosis (SSc) associated with moyamoya syndrome (MMS) is a clinically rare disease. To further understand the clinical characteristics of S......

Correlation between serum levels of endothelin-1 and disease severity in patients with neuromyelitis optica spectrum disorders

期刊: IMMUNOBIOLOGY, 2020; 225 (3)

Aims: Neuromyelitis optica spectrum disorders (NMOSD) are aquaporin-4 antibody-mediated diseases of the central nervous system. Endothelin-1 (ET-1) is......

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