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An efficient and general method for the synthesis of stable isotope deuterium labeled phthalate esters

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2021; 64 (10)

An efficient and general synthetic route of deuterium-labeled phthalate esters is described with high isotopic enrichment and excellent chemical purit......

Preparation and biological evaluation of radioiodine-labeled triphenylphosphine derivatives as mitochondrial targeting probes

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2021; 64 (7)

The positive-charged lipophilic triphenylphosphonium cations (TPPs(+)) have been served as mitochondrial targeting vehicles for the delivery of variou......

Research on preparation and in vitro evaluation of the dendrimer-peptide nuclear acid conjugate for amplification pretargeting

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2021; 64 (11)

Amplification pretargeting has the potential to increase the tracer's accumulation in the tumor. This study aimed to develop a three-step amplificatio......

A facile synthesis of isotope labeled acylcarnitines

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, ; ()

Acylcarnitines are a big family of small molecule metabolites with various acyl groups attached to the hydroxyl moiety of l-carnitine. They are good i......

Positron emission tomography imaging of a novel Anxa1-targeted peptide(18)F-Al-NODA-Bn-p-SCN-GGGRDN-IF7 in A431 cancer mouse models

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2020; 63 (12)

Annexin 1 (Anxa1) is a highly specific surface marker of tumor vasculature in the lung and prostate solid tumors. The IF7 peptide was modified with a ......

Synthesis of(18)F-radiolabeled organophosphine fluorides for thiol-chemoselective peptide conjugation

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2020; 63 (14)

Two(18)F-radiolabeled organofluorophosphine fluorides ([F-18]4and [F-18]7) for chemoselective thiol-conjugation were designed and synthesized via(18)F......

An improved preparation of [F-18]AV-45 by simplified solid-phase extraction purification

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2020; 63 (3)

Amyvid (florbetapir f18, [F-18]AV-45, [F-18]5) was the first FDA-approved positron emission tomography imaging agent targeting beta-amyloid (A beta) p......

A concisely automated synthesis of TSPO radiotracer [F-18]FDPA based on spirocyclic iodonium ylide method and validation for human use

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2020; 63 (3)

Fluorine-18 labeled N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ([F-18]FDPA) is a potent and selec......

Radiolabeled (R)-(-)-5-iodo-3 '-O-[2-(epsilon-guanidinohexanoyl)-2-phenylacetyl]-2 '-deoxyuridine: A new theranostic for neuroblastoma

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2020; 63 (7)

Neuroblastoma, the most common extracranial solid tumor in children, accounts for nearly 8% of childhood cancers in the United States. It is a disease......

Radiosynthesis of novel N-F-18-labeled F-18-FHex-alpha-l-Glu and F-18-FHex-beta-Glu

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2020; 63 (5)

N-F-18-labeled amino acids are important substitutes for new positron emission tomography (PET) imaging tracers complementing the deficiency of F-18-f......

A Cu-64-porphyrin-based dual-modal molecular probe with integrin alpha(v)beta(3) targeting function for tumour imaging

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2020; 63 (5)

Pyropheophorbide-a (Pyro) is a promising multifunctional molecule for multimodal tumour imaging and photodynamic therapy, but its clinical application......

Radioiodinated progesterone derivative for progesterone receptor targeting with enhanced nucleus uptake via phenylboronic acid conjugation

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2019; 62 (7)

A novel I-131-radiolabeled probe with aromatic boronate motif (I-131-EIPBA) was designed to target progesterone receptor (PR)-positive breast cancer w......

JIF:1.29

Radiolabeling, quality control, biodistribution, and imaging studies of Lu-177-ibandronate

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2019; 62 (1)

The purposes of this study were as follows: (1) to radiolabel ibandronic acid (IBA, a third-generation bisphosphonate) with Lu-177, investigating opti......

JIF:1.29

Identification of unexpected unlabeled N,N-dimethylamide formation in the synthesis of deuterated fragment of ribociclib by a HATU-mediated coupling reaction

期刊: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2019; 62 (2)

Starting from N,N-dimethylamine and D2O, deuterated fragment of ribociclib was synthesized for use as a mass spectroscopy internal standard. Furthermo......

JIF:1.29

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