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Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage

期刊: EXPERIMENTAL NEUROLOGY, 2021; 341 ()

Triggering receptor expressed on myeloid cells-1 (TREM-1) was found to be induced in the context of subarachnoid hemorrhage (SAH) before. This study f......

The protective effect and potential mechanism of NRXN1 on learning and memory in ADHD rat models

期刊: EXPERIMENTAL NEUROLOGY, 2021; 344 ()

The learning and memory network is highly complex and remains unclear. The hippocampus is the location of learning and memory function. Impairment of ......

Preconditioning increases brain resistance against acute brain injury via neuroinflammation modulation

期刊: EXPERIMENTAL NEUROLOGY, 2021; 341 ()

Acute brain injury (ABI) is a broad concept mainly comprised of sudden parenchymal brain injury. Acute brain injury outcomes are dependent not only on......

Pseudoginsenoside F11 ameliorates the dysfunction of the autophagy-lysosomal pathway by activating calcineurin-mediated TFEB nuclear translocation in neuron during permanent cerebral ischemia

期刊: EXPERIMENTAL NEUROLOGY, 2021; 338 ()

We have previously found that transcription factor EB (TFEB), as a master regulator of autophagy and lysosome biogenesis, provides neuroprotective eff......

Ruxolitinib exerts neuroprotection via repressing ferroptosis in a mouse model of traumatic brain injury

期刊: EXPERIMENTAL NEUROLOGY, 2021; 342 ()

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Various forms of cells death are involved in the pathological process......

Three-dimensional in vitro tissue culture models of brain organoids

期刊: EXPERIMENTAL NEUROLOGY, 2021; 339 ()

Brain organoids are three-dimensional self-assembled structures that are derived from human induced pluripotent stem cells (hiPSCs). They can recapitu......

Presynaptic inputs to vasopressin neurons in the hypothalamic supraoptic nucleus and paraventricular nucleus in mice

期刊: EXPERIMENTAL NEUROLOGY, 2021; 343 ()

Arginine vasopressin (AVP) neurons in the hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN) are involved in important physiologi......

Inputs from paraventricular nucleus of thalamus and locus coeruleus contribute to the activation of central nucleus of amygdala during context-induced retrieval of morphine withdrawal memory

期刊: EXPERIMENTAL NEUROLOGY, 2021; 338 ()

Drug relapse can be mainly ascribed to the retrieval of drug withdrawal memory induced by conditioned context. Previous studies have shown that the ce......

MiR-706 alleviates white matter injury via downregulating PKC alpha/MST1/NF-kappa B pathway after subarachnoid hemorrhage in mice

期刊: EXPERIMENTAL NEUROLOGY, 2021; 341 ()

Increasing numbers of patients with spontaneous subarachnoid hemorrhage(SAH) who recover from surgery and intensive care management still live with co......

ZNRF2 attenuates focal cerebral ischemia/reperfusion injury in rats by inhibiting mTORC1-mediated autophagy

期刊: EXPERIMENTAL NEUROLOGY, 2021; 342 ()

Zinc and ring finger 2 (ZNRF2), an E3 ubiquitin ligase, plays a crucial role in many diseases. However, its role in cerebral ischemia/reperfusion inju......

PPM1F in hippocampal dentate gyrus regulates the depression-related behaviors by modulating neuronal excitability

期刊: EXPERIMENTAL NEUROLOGY, 2021; 340 ()

Major depressive disorder (MDD) is a common, serious, debilitating mental illness. Protein phosphatase Mg2+/ Mn2+-dependent 1F (PPM1F), a serine/threo......

Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes

期刊: EXPERIMENTAL NEUROLOGY, 2021; 341 ()

Background: Pyroptosis mediated by NLRP3 inflammasome plays a critical role in the pathogenesis of cerebral ischemia-reperfusion (I/R) injury. Mountin......

The convergence of aversion and reward signals in individual neurons of the mice lateral habenula

期刊: EXPERIMENTAL NEUROLOGY, 2021; 339 ()

The lateral habenula (LHb) and ventral tegmental area (VTA) are two structures closely connected, and they serve as aversion and reward junction of th......

The p75 neurotrophin receptor as a novel intermediate in L-dopa-induced dyskinesia in experimental Parkinson's disease

期刊: EXPERIMENTAL NEUROLOGY, 2021; 342 ()

In Parkinson's disease (PD), long-term administration of L-dopa often leads to L-dopa-induced dyskinesia (LID), a debilitating motor complication. The......

miR-31 from adipose stem cell-derived extracellular vesicles promotes recovery of neurological function after ischemic stroke by inhibiting TRAF6 and IRF5

期刊: EXPERIMENTAL NEUROLOGY, 2021; 342 ()

Ischemic stroke affects many people in the world, but the underlying mechanism is not completely understood. In this study, we investigated the effect......

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