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STAT3 promotes peritoneal metastasis of gastric cancer by enhancing mesothelial-mesenchymal transition

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (6)

Signal transducer and activator of transcription 3 (STAT3) is a widely-reported oncogene in many human cancers, but its role in the peritoneal metasta......

Dihydroartemisinin ameliorates balloon injury-induced neointimal formation through suppressing autophagy in vascular smooth muscle cells

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (4)

The present study was designed to investigate the therapeutic effects of injection of dihydroartemisinin (DHA) into the balloon-injured carotid arteri......

Carotenoids in Sporidiobolus pararoseus ameliorate diabetic nephropathy in mice through attenuating oxidative stress

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (7)

Diabetic nephropathy (DN) is the major life-threatening complication of diabetes, and oxidative stress takes part in its initiation and development. T......

Berberine improves dietary-induced cardiac remodeling by upregulating Kruppel-like factor 4-dependent mitochondrial function

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (7)

Multiple studies have showed that berberine protects against heart diseases, including obesity-associated cardiomyopathy. However, it is not fully dis......

TFAP2A-induced SLC2A1-AS1 promotes cancer cell proliferation

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (6)

Long non-coding RNAs (lncRNAs) are involved in the occurrence and development of human cancers including lung adenocarcinoma (LUAD). SLC2A1-AS1 is a n......

Decreased level of miR-1301 promotes colorectal cancer progression via activation of STAT3 pathway

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (7)

The molecular pathogenesis of colorectal cancer (CRC) has been widely investigated in recent years. Accumulating evidence has indicated that microRNA ......

Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (7)

Porphyromonas gingivalis is a bacterial species known to be involved in the pathogenesis of chronic periodontitis, that more recently has been as well......

JMJD3-regulated expression of IL-6 is involved in the proliferation and chemosensitivity of acute myeloid leukemia cells

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (7)

Emerging evidence shows that histone modification and its related regulators are involved in the progression and chemoresistance of multiple tumors in......

IL-24 inhibits the malignancy of human glioblastoma cells via destabilization of Zeb1

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (7)

Glioblastoma (GBM) is the most common and fatal type of primary malignant tumours in the central nervous system. Cytokines such as interleukins (ILs) ......

C-X-C chemokine receptor 2 (Cxcr2) promotes hepatocellular carcinoma immune evasion via regulating programmed death-ligand 1 (PD-L1)

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (6)

Strategies to sensitize hepatocellular carcinomas (HCC) to programmed death-1 (PD1)/programmed death-ligand 1 (PD-L1) inhibitor therapies are importan......

HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (4)

The chemoresistance is one of the major challenges for acute myeloid leukemia (AML) treatment. We found that the expression of histone deacetylase 8 (......

Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (6)

Liver fibrosis is a common consequence of chronic liver diseases involved with the activation of hepatic stellate cells (HSCs) and endoplasmic reticul......

PCAT1 induced by transcription factor YY1 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-216a-3p to up-regulate oncogene BCL3

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (2)

This studywas designed to illustrate the function and role of PCAT1 in CCA. The relative expression was confirmed by RT-qPCR and western blot. The bio......

ADAM8 affects glioblastoma progression by regulating osteopontin-mediated angiogenesis

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (2)

Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer with a median survival of only 15 months. To complement standard treatments ......

Computational study for suppression of CD25/IL-2 interaction

期刊: BIOLOGICAL CHEMISTRY, 2021; 402 (2)

Cancer recurrence presents a huge challenge in cancer patient management. Immune escape is a key mechanism of cancer progression and metastatic dissem......

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