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Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and Cardiac Rhythm Maintenance

期刊: CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2022; 15 (5)

BACKGROUND: Idiopathic ventricular tachycardia (VT) occurs in structurally normal hearts and accounts for a significant number of all types of VT. The......

Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry

期刊: CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2021; 14 (4)

Background: Lp(a) (lipoprotein [a]) levels are higher in individuals of African ancestry (AA) than in individuals of European ancestry (EA). We examin......

Cadherin 2-Related Arrhythmogenic Cardiomyopathy Prevalence and Clinical Features

期刊: CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2021; 14 (2)

Background: Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease characterized by fibrofatty replacement of the right and left ventricl......

Validation and Disease Risk Assessment of Previously Reported Genome-Wide Genetic Variants Associated With Brugada Syndrome SADS-TW BrS Registry

期刊: CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2020; 13 (4)

Background: Brugada syndrome (BrS) is an oligogenic arrhythmic disease with increased risk of sudden cardiac arrest. Several BrS or ECG traits-related......

Genotype-Guided Dosing of Warfarin in Chinese Adults A Multicenter Randomized Clinical Trial

期刊: CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2020; 13 (4)

BACKGROUND: Warfarin is an effective treatment for thromboembolic disease but has a narrow therapeutic index; optimal anticoagulation dosage can diffe......

Noncoding RNAs in Cardiovascular Disease: Current Knowledge, Tools and Technologies for Investigation, and Future Directions: A Scientific Statement From the American Heart Association

期刊: CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2020; 13 (4)

Background: The discovery that much of the non-protein-coding genome is transcribed and plays a diverse functional role in fundamental cellular proces......

Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 That Are Common in Chinese Patients

期刊: CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2020; 13 (5)

Background: To assess the genetic architecture of hypertrophic cardiomyopathy (HCM) in patients of predominantly Chinese ancestry. Methods: We sequenc......

Monoallelic Mutations in CC2D1A Suggest a Novel Role in Human Heterotaxy and Ciliary Dysfunction

期刊: CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2020; 13 (6)

Background: Human heterotaxy is a group of congenital disorders characterized by misplacement of one or more organs according to the left-right axis. ......

Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

期刊: CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2020; 13 (6)

BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). METHODS: To test whether this reflects diffe......

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