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Depletion of the gut microbiota differentially affects the impact of whey protein on high-fat diet-induced obesity and intestinal permeability

期刊: PHYSIOLOGICAL REPORTS, 2021; 9 (11)

Whey protein isolate (WPI) is considered a dietary solution to obesity. However, the exact mechanism of WPI action is still poorly understood but is p......

Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity

期刊: PHYSIOLOGICAL REPORTS, 2021; 9 (16)

Obesity, type 2 diabetes, and heart disease are linked to an unhealthy diet. Sarco(endo)plasmic reticulum calcium (Ca2+) ATPase 2a (SERCA2a) controls ......

A hierarchical dynamic model used for investigating feed efficiency and its relationship with hepatic gene expression in APOE*3-Leiden.CETP mice

期刊: PHYSIOLOGICAL REPORTS, 2021; 9 (8)

Background Feed efficiency (FE) is an important trait for livestock and humans. While the livestock industry focuses on increasing FE, in the current ......

Pharmacological inhibition of dynamin-related protein 1 attenuates skeletal muscle insulin resistance in obesity

期刊: PHYSIOLOGICAL REPORTS, 2021; 9 (7)

Dynamin-related protein-1 (Drp1) is a key regulator in mitochondrial fission. Excessive Drp1-mediated mitochondrial fission in skeletal muscle under t......

Pro)renin receptor antagonist PRO20 attenuates nephrectomy-induced nephropathy in rats via inhibition of intrarenal RAS and Wnt/beta-catenin signaling

期刊: PHYSIOLOGICAL REPORTS, 2021; 9 (11)

Introduction: (Pro)renin receptor has emerged as a new member of the renin-angiotensin system implicated in the pathogenesis of chronic kidney disease......

Autoimmune activation of the GnRH receptor induces insulin resistance independent of obesity in a female rat model

期刊: PHYSIOLOGICAL REPORTS, 2021; 8 (24)

Polycystic ovary syndrome (PCOS), a metabolic and reproductive disease, is frequently associated with type 2 diabetes. We have demonstrated activating......

Inflammation and enhanced atherogenesis in the carotid artery with altered blood flow in an atherosclerosis-resistant mouse strain

期刊: PHYSIOLOGICAL REPORTS, 2021; 9 (11)

Ligation of the common carotid artery near its bifurcation in apolipoprotein-E-deficient (Apoe(-/-)) mice leads to rapid atherosclerosis development, ......

Reduced fecal short-chain fatty acids in hispanic children with ulcerative colitis

期刊: PHYSIOLOGICAL REPORTS, 2021; 9 (14)

Background: It is known that patients with ulcerative colitis (UC) have reduced numbers of short-chain fatty acid (SCFA) producing bacteria and reduce......

Cortisol level dysregulation and its prevalence-Is it nature's alarm clock?

期刊: PHYSIOLOGICAL REPORTS, 2021; 8 (24)

This review examines the stress hormone cortisol which plays an important role in regulating and supporting different bodily functions. Disruption in ......

Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells

期刊: PHYSIOLOGICAL REPORTS, 2021; 9 (2)

Chronic kidney disease (CKD) has a high prevalence worldwide and is an intricate issue to whole medical society. Renal fibrosis is the common patholog......

Genetic susceptibility of hypertension-induced kidney disease

期刊: PHYSIOLOGICAL REPORTS, 2021; 9 (1)

Hypertension is the second leading cause of end-stage renal disease (ESRD) after diabetes mellitus. The significant differences in the incidence of hy......

Panspecies molecular assays detect viral pathogens missed by real-time PCR/reverse-transcriptase PCR among pneumonia patients, Sarawak, Malaysia

期刊: TROPICAL DISEASES TRAVEL MEDICINE AND VACCINES, 2020; 6 (1)

Background In a year-long pneumonia etiology study conducted June 2017 to May 2018 in Sarawak, Malaysia, 599 patients' nasopharyngeal swab specimens w......

Serum levels of sLOX-1 and Lp-PLA2 can predict the prognosis of acute cerebral infarction with a high specificity

期刊: PHYSIOLOGICAL REPORTS, 2022; 10 (1)

Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) and lipoprotein-associated phospholipase A2 (Lp-PLA2) plays an important role......

Potential biomarkers and therapeutic targets of idiopathic pulmonary arterial hypertension

期刊: PHYSIOLOGICAL REPORTS, 2022; 10 (1)

Background: Peripheral blood mononuclear cells (PBMCs) play an important role in the pathogenesis of pulmonary arterial hypertension (PAH). However, t......

Quantitative assessment of multichannel intraluminal impedance pH and its clinical implications

期刊: PHYSIOLOGICAL REPORTS, 2022; 10 (4)

We sought to quantify the characteristics of acid reflux episodes in patients with extraesophageal GERD symptoms (EES), hiatal hernia (HH), and erosiv......

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