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Computational Analysis of Domains Vulnerable to HPV-16 E6 Oncoprotein and Corresponding Hot Spot Residues

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (4)

Background: Human Papilloma Virus (HPV) is the primary cause of cancers in cervix, head and neck regions. Oncoprotein E6 of HPV-16, after infecting hu......

Biochemical Study of Fibrinolytic Protease from Euphausia superba Possessing Multifunctional Serine Protease Activity

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (6)

Background: Fibrinolytic protease from Euphausia superba (EFP) was isolated. Objective: Biochemical distinctions, regulation of the catalytic function......

Potential Application of CRISPR/Cas9 System to Engineer Abiotic Stress Tolerance in Plants

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (8)

Abiotic stresses in plants such as salinity, drought, heavy metal toxicity, heat, and nutrients limitations significantly reduce agricultural producti......

Molecular Insights into Zn2+ Inhibition of the Antibacterial Endopeptidase Lysostaphin from Staphylococcus simulans

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (2)

Background: Mature lysostaphin (similar to 28-kDa Lss) from Staphylococcus simulans proves effective in killing methicillin-resistant Staphylococcus a......

Soluble Expression, One-Step Purification and Characterization of Recombinant Human Growth Hormone Fused with ompA3 in Escherichia coli

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (5)

Results: High-level expression (800 mu g/mL) was achieved by induction with 0.5 mM IPTG at 30 degrees C for 10 hours. The purity of hGH was over 90%. ......

Fusion Expression and Fibrinolytic Activity of rPA/SP-B

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (9)

Background: Pulmonary surfactant dysfunction is an important pathological factor in acute respiratory distress syndrome (ARDS) and pulmonary fibrosis ......

Facile Synthesis of Boc-Protected Selenocystine and its Compatibility with Late-Stage Farnesylation at Cysteine Site

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (6)

Background: The unique hypervariable C-terminal region (HVR) of K-Ras4B, one of the most frequently mutated proteins in many powerful cancers, contain......

A Thermostable Aluminum-Tolerant Protease Produced Feather-Degrading Bacillus thuringiensis Isolated from Tea Plantation

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (5)

Background: Proteases with keratinolytic activity are widely used in biotechnologies. The feather-degrading Bacillus thuringensis isolated from soil s......

Transmembrane Protein 166 and its Significance

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (4)

Transmembrane protein 166 (TMEM166) is a lysosomal/endoplasmic reticulum (ER)-associated protein found in different species where it functions as a re......

Purification of Classical Swine Fever Virus E2 Subunit Vaccines Based on High Affinity Peptide Ligand

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (5)

Background: The purification of expressed proteins is the most critical part of subunit -vaccine production. Protein-purification methods such as affi......

Evolution and Structure of API5 and Its Roles in Anti-Apoptosis

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (6)

Apoptosis, also named programmed cell death, is a highly conserved physiological mechanism. Apoptosis plays crucial roles in many life processes, such......

Heterologous Expression and Application of Multicopper Oxidases from Enterococcus spp. for Degradation of Biogenic Amines

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (2)

Background: Biogenic amines are harmful to human health at a certain extent. As a kind of biogenic amine oxidase, multicopper oxidase can be used to d......

Crystal Structure of a Cu,Zn Superoxide Dismutase From Thermophilic Fungus Chaetomium thermophilum

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (9)

Background: Thermophilic fungi have recently emerged as a promising source of thermostable enzymes. Superoxide dismutases are key antioxidant metalloe......

Spider Silks: An Overview of Their Component Proteins for Hydrophobicity and Biomedical Applications

期刊: PROTEIN AND PEPTIDE LETTERS, 2021; 28 (3)

Spider silks have received extensive attention from scientists and industries around the world because of their remarkable mechanical properties, whic......

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