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Burn-induced heterotopic ossification from incidence to therapy: key signaling pathways underlying ectopic bone formation

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Burn injury is one of the potential causes of heterotopic ossification (HO), which is a rare but debilitating condition. The incidence ranges from 3.5......

MiR-501 promotes tumor proliferation and metastasis by targeting HOXD10 in endometrial cancer

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Background Several studies have shown the crucial role of miR-501 in regulating cellular pathology in various cancers. However, the function and expre......

Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Background Currently, resistance against cisplatin (DDP) is a frequent problem for the success of advanced gastric carcinoma (GC) chemotherapy. Here, ......

LncRNA UCA1 promotes development of gastric cancer via the miR-145/MYO6 axis

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Background Long noncoding RNA (lncRNA), urothelial carcinoma-associated 1 (UCA1) is aberrantly expressed in multiple cancers and has been verified as ......

beta-acetoxyisovaleryl alkannin (AAN-II) from Alkanna tinctoria promotes the healing of pressure-induced venous ulcers in a rabbit model through the activation of TGF-beta/Smad3 signaling

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Alkannin-based pharmaceutical formulations for improving wound healing have been on the market for several years. However, detailed molecular mechanis......

Actin polymerization state regulates osteogenic differentiation in human adipose-derived stem cells

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Background Actin is an essential cellular protein that assembles into microfilaments and regulates numerous processes such as cell migration, maintena......

Regulatory role of local tissue signal Del-1 in cancer and inflammation: a review

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Developmental endothelial locus-1 (Del-1) is a secretory, multifunctional domain protein. It can bind to integrins and phosphatidylserine. As a local ......

Targeting the GPR119/incretin axis: a promising new therapy for metabolic-associated fatty liver disease

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

In the past decade, G protein-coupled receptors have emerged as drug targets, and their physiological and pathological effects have been extensively s......

Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1 alpha

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Background Some natural compounds inhibit cancer cell growth in various cancer cell lines with fewer side effects than traditional chemotherapy. Here,......

Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Most currently recommended therapies for metabolic dysfunction-associated fatty liver disease (MAFLD) involve diet control and exercise therapy. We se......

Manganese (II) chloride leads to dopaminergic neurotoxicity by promoting mitophagy through BNIP3-mediated oxidative stress in SH-SY5Y cells

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Background Manganese overexposure can induce neurotoxicity, lead to manganism and result in clinical manifestations similar to those of parkinsonism. ......

beta-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Background: We have previously found that beta-elemene could inhibit the viability of airway granulation fibroblasts and prevent airway hyperplastic s......

LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Background Improved chondrogenic differentiation of mesenchymal stem cells (MSCs) by genetic regulation is a potential method for regenerating articul......

Apoptosis-promoting properties of miR-3074-5p in MC3T3-E1 cells under iron overload conditions

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Background: Iron overload can promote the development of osteoporosis by inducing apoptosis in osteoblasts. However, the mechanism by which miRNAs reg......

Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A

期刊: CELLULAR & MOLECULAR BIOLOGY LETTERS, 2021; 26 (1)

Background The suppressive effects of miR-33a-5p have been reported in colorectal cancer and lung cancer. However, the functional role of miR-33a-5p i......

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