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Effect of Shuangdan Mingmu capsule, a Chinese herbal formula, on oxidative stress-induced apoptosis of pericytes through PARP/GAPDH pathway

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background Diabetic retinopathy (DR) has become a worldwide concern because of the rising prevalence rate of diabetes mellitus (DM). Despite much ener......

Protective effect of Glechoma hederacea extract against gallstone formation in rodent models

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background: Our current study aimed to evaluate the effect of an Glechoma hederacea extract (Hitrechol (R)) in normal rats and gallstone diseased mice......

Bupi Yishen formula attenuates kidney injury in 5/6 nephrectomized rats via the tryptophan-kynurenic acid-aryl hydrocarbon receptor pathway

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background Bupi Yishen Formula (BYF), a patent traditional Chinese medicine (TCM) formulation, has been used in the clinical treatment of chronic kidn......

Effects of Stephania hainanensis alkaloids on MSU-induced acute gouty arthritis in mice

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background Gout is initiated by the precipitation of monosodium urate (MSU) crystals within the joints and soft tissues, and it can eventually cause a......

Homogeneous polyporus polysaccharide inhibits bladder cancer by polarizing macrophages to M1 subtype in tumor microenvironment

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background: Polyporus polysaccharide (PPS), an active ingredient of traditional Chinese medicinal Polyporus umbellatus, has multiple biological functi......

Therapeutic effect of various ginsenosides on rheumatoid arthritis

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background Rheumatoid arthritis (RA) is an autoimmune disease which causes disability and threatens the health of humans. Therefore, it is of great si......

Ethanol extract of mulberry leaves partially restores the composition of intestinal microbiota and strengthens liver glycogen fragility in type 2 diabetic rats

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background Mulberry leaf as a traditional Chinese medicine is able to treat obesity, diabetes, and dyslipidemia. It is well known that diabetes leads ......

Molecular mechanism of Epicedium treatment for depression based on network pharmacology and molecular docking technology

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background Increasing attention has been paid to the effect of Epimedium on the nervous system, particularly anti-depression function. In the present ......

A network pharmacology-based investigation on the bioactive ingredients and molecular mechanisms of Gelsemium elegans Benth against colorectal cancer

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background Colorectal cancer (CRC) remains one of the leading causes of cancer-related death worldwide. Gelsemium elegans Benth (GEB) is a traditional......

Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKII gamma/c-Myc/CDK6 signaling pathway

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background: C-Myc aberrations confer a more aggressive clinic behavior in diffuse large B-cell lymphoma (DLBCL). Matrine is an alkaloid extracted from......

Ameliorated biomechanical properties of carotid arteries by puerarin in spontaneously hypertensive rats

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background An emerging body of evidence indicates that puerarin (PUE) plays an important role in the treatment of angina pectoris, myocardial ischemia......

Acupuncture for post-stroke depression: a systematic review and meta-analysis

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

BackgroundAcupuncture for post-stroke depression (PSD) has been evolving, but uncertainty remains. To assess the existing evidence from randomized cli......

Lipidomics study of the therapeutic mechanism of Plantaginis Semen in potassium oxonate-induced hyperuricemia rat

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background Plantaginis Semen has been widely used as folk medicine and health care food against hyperuricemia (HUA) and gout, but its pharmacological ......

Vincetoxicum arnottianum modulates motility features and metastatic marker expression in pediatric rhabdomyosarcoma by stabilizing the actin cytoskeleton

期刊: BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021; 21 (1)

Background: Prevention of metastatic invasion is one of the main challenges in the treatment of alveolar rhabdomyosarcoma. Still the therapeutic optio......

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