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CREG ameliorates embryonic stem cell differentiation into smooth muscle cells by modulation of TGF-beta expression

期刊: DIFFERENTIATION, 2022; 125 ()

Vascular smooth muscle cell (SMCs) differentiation is critical for cardiovascular development, but the mechanisms remain largely unknown. The overall ......

JIF:2.38

Inhibition of smoothened receptor by vismodegib leads to micrognathia during embryogenesis

期刊: DIFFERENTIATION, 2022; 125 ()

The mandible is an important part of the craniofacial skeleton. Mandibular development is complex and involves multiple signaling pathways. These sign......

JIF:2.38

CircAMD1 regulates proliferation and collagen synthesis via sponging miR-27a-3p in P63-mutant human dermal fibroblasts

期刊: DIFFERENTIATION, 2021; 119 ()

Transcription factor p63 has critical functions in epidermal, hindgut/anorectal, and limb development. Human mutations in P63 correlate with congenita......

Mesenchyme homeobox 1 mediated-promotion of osteoblastic differentiation is negatively regulated by mir-3064-5p

期刊: DIFFERENTIATION, 2021; 120 ()

Human mesenchymal stem cells (hMSCs) are multipotent cells that can be differentiated into different cell types including osteoblasts. Herein we aimed......

In vitro and in vivo study on angiogenesis of porcine induced pluripotent stem cell-derived endothelial cells

期刊: DIFFERENTIATION, 2021; 120 ()

Pluripotent stem cells (PSCs) are a promising source of endothelial cells (ECs) for the treatment of cardiovascular diseases. Since clinical applicati......

CircRNAs and LncRNAs in Osteoporosis

期刊: DIFFERENTIATION, 2020; 116 ()

Osteoporosis is a systemic bone disease with bone fragility and increased fracture risk. The non-coding RNAs (ncRNAs) have appeared as important regul......

The involvement of hsa_circ_0000417 in the development of hypospadias by regulating AR

期刊: DIFFERENTIATION, 2020; 116 ()

Background: Congenital hypospadias is a common congenital malformation of the urinary system in male children. However, the role of circRNA in congeni......

LINC00968 promotes osteogenic differentiation in vitro and bone formation in vivo via regulation of miR-3658/RUNX2

期刊: DIFFERENTIATION, 2020; 116 ()

Osteogenic differentiation of dental pulp stem cells (DPSCs) is considered as a promising strategy in posterior maxilla tooth implantation. Informatio......

A crucial role of fibroblast growth factor 2 in the differentiation of hair follicle stem cells toward endothelial cells in a STAT5-dependent manner

期刊: DIFFERENTIATION, 2020; 111 ()

Fibroblast growth factor (FGF2) is reported to affect the proliferation, differentiation, and survival abilities of stem cells. In this study, we hypo......

SHED-derived conditioned exosomes enhance the osteogenic differentiation of PDLSCs via Wnt and BMP signaling in vitro

期刊: DIFFERENTIATION, 2020; 111 ()

The exosomes from human exfoliated deciduous teeth (SHED-Exos) have exhibited potential therapeutic role in dental and oral disorders. The biological ......

Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells

期刊: DIFFERENTIATION, 2020; 112 ()

Idiopathic pulmonary fibrosis (IPF) is a serious lung disease that involved the myofibroblast differentiation of lung resident mesenchymal stem cells ......

The multiple roles of Thy-1 in cell differentiation and regeneration

期刊: DIFFERENTIATION, 2020; 113 ()

Thy-1 is a 25-37 kDa glycophosphatidylinositol (GPI)-anchored cell surface protein that was discovered more than 50 years ago. Recent findings have su......

Spatial and temporal deletion reveals a latent effect of Megf8 on the left-right patterning and heart development

期刊: DIFFERENTIATION, 2020; 113 ()

Laterality disease is frequently associated with congenital heart disease (CHD). However, it is unclear what is behind this association, a pleiotropic......

Roles of circular RNAs in regulating the self-renewal and differentiation of adult stem cells

期刊: DIFFERENTIATION, 2020; 113 ()

Circular RNAs (circRNAs) are a type of noncoding RNA (ncRNA) and have attracted widespread research attention in recent years. They form a covalently ......

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