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Altered Relationship Between Parvalbumin and Perineuronal Nets in an Autism Model

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

Altered function or presence of inhibitory neurons is documented in autism spectrum disorders (ASD), but the mechanism underlying this alternation is ......

Single-Nucleus Chromatin Accessibility Landscape Reveals Diversity in Regulatory Regions Across Distinct Adult Rat Cortex

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

Rats have been widely used as an experimental organism in psychological, pharmacological, and behavioral studies by modeling human diseases such as ne......

Long Non-coding RNA LINC01119 Promotes Neuropathic Pain by Stabilizing BDNF Transcript

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

Neuropathic pain (NP) is caused by primary injury or dysfunction of the peripheral and the central nervous system. Long non-coding RNAs were critical ......

Inhibition of the NKCC1/NF-kappa B Signaling Pathway Decreases Inflammation and Improves Brain Edema and Nerve Cell Apoptosis in an SBI Rat Model

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

Surgical brain injury (SBI) triggers microglia to release numerous inflammatory factors, leading to brain edema and neurological dysfunction. Reducing......

Transcriptome Analysis Reveals the Role of Cellular Calcium Disorder in Varicella Zoster Virus-Induced Post-Herpetic Neuralgia

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

As a typical neuropathic pain, post-herpetic neuralgia (PHN) is a common complication of herpes zoster (HZ), which seriously affects the normal life a......

MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

The regulation of microRNA (miRNA) is closely related to methamphetamine (METH) addiction. Past studies have reported that miR-181a is associated with......

The Role of Calmodulin vs. Synaptotagmin in Exocytosis

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

Exocytosis is a Ca2+-regulated process that requires the participation of Ca2+ sensors. In the 1980s, two classes of Ca2+-binding proteins were propos......

Astrocytic and Oligodendrocytic P2X7 Receptors Determine Neuronal Functions in the CNS

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

P2X7 receptors are members of the ATP-gated cationic channel family with a preferential localization at the microglial cells, the resident macrophages......

The P2X(7) Receptor Is Involved in Diabetic Neuropathic Pain Hypersensitivity Mediated by TRPV1 in the Rat Dorsal Root Ganglion

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

The purinergic 2X(7) (P2X(7)) receptor expressed in satellite glial cells (SGCs) is involved in the inflammatory response, and transient receptor pote......

Pathogenic Functions of Tumor Necrosis Factor Receptor-Associated Factor 6 Signaling Following Traumatic Brain Injury

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

Neuroinflammation contributes to delayed (secondary) neurodegeneration following traumatic brain injury (TBI). Tumor necrosis factor receptor-associat......

CircRNA-ceRNA Network Revealing the Potential Regulatory Roles of CircRNA in Alzheimer's Disease Involved the cGMP-PKG Signal Pathway

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

Background: Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease. The characteristic pathologies include extracellular senile p......

The Potential Effect of Na(v)1.8 in Autism Spectrum Disorder: Evidence From a Congenital Case With Compound Heterozygous SCN10A Mutations

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

Apart from the most prominent symptoms in Autism spectrum disorder (ASD), namely deficits in social interaction, communication and repetitive behavior......

Astroglial Connexins in Neurodegenerative Diseases

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

Astrocytes play a crucial role in the maintenance of the normal functions of the Central Nervous System (CNS). During the pathogenesis of neurodegener......

Role of the Ubiquitin System in Chronic Pain

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 14 ()

As a significant public health issue, chronic pain, mainly neuropathic pain (NP) and inflammatory pain, has a severe impact. The underlying mechanisms......

Rapamycin Preserves Neural Tissue, Promotes Schwann Cell Myelination and Reduces Glial Scar Formation After Hemi-Contusion Spinal Cord Injury in Mice

期刊: FRONTIERS IN MOLECULAR NEUROSCIENCE, 2021; 13 ()

Protecting white matter is one of the key treatment strategies for spinal cord injury (SCI), including alleviation of myelin loss and promotion of rem......

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