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Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine

期刊: BLOOD CANCER DISCOVERY, 2022; 3 (6)

Despite the expanding portfolio of targeted therapies for adults with acute myeloid leukemia (AML), direct implementation in children is challenging d......

Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins

期刊: BLOOD CANCER DISCOVERY, 2021; 2 (4)

The PML/RAR alpha fusion protein is the oncogenic driver in acute promyelocytic leukemia (APL). Although most APL cases are cured by PML/RAR alpha-tar......

Bortezomib Induces Immunogenic cell Death in Multiple Myeloma

期刊: BLOOD CANCER DISCOVERY, 2021; 2 (5)

As a general rule, successful antineoplastic treatments induce an antitumor immune response, even if they were initially designed to target cancer cel......

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