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Meningitic Escherichia coli alpha-hemolysin aggravates blood-brain barrier disruption via targeting TGF beta 1-triggered hedgehog signaling

期刊: MOLECULAR BRAIN, 2021; 14 (1)

Bacterial meningitis is a life-threatening infectious disease with severe neurological sequelae and a high mortality rate, in which Escherichia coli i......

NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice

期刊: MOLECULAR BRAIN, 2021; 14 (1)

Introduction N-Methyl-D-aspartate receptors (NMDARs) play a critical role in different forms of plasticity in the central nervous system. NMDARs are a......

Multiple synaptic connections into a single cortical pyramidal cell or interneuron in the anterior cingulate cortex of adult mice

期刊: MOLECULAR BRAIN, 2021; 14 (1)

The ACC is an important brain area for the processing of pain-related information. Studies of synaptic connections within the ACC provide an understan......

Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort

期刊: MOLECULAR BRAIN, 2021; 14 (1)

Objective: To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults. Methods: The SNPs associat......

Cirbp-PSD95 axis protects against hypobaric hypoxia-induced aberrant morphology of hippocampal dendritic spines and cognitive deficits

期刊: MOLECULAR BRAIN, 2021; 14 (1)

Hypobaric hypoxia (HH) is a typical characteristic of high altitude environment and causes a spectrum of pathophysiological effects, including headach......

Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy

期刊: MOLECULAR BRAIN, 2021; 14 (1)

Clock genes not only regulate the circadian rhythm of physiological activities but also participate in the pathogenesis of many diseases. Previous stu......

The role m(6)A RNA methylation is CNS development and glioma pathogenesis

期刊: MOLECULAR BRAIN, 2021; 14 (1)

Epigenetic abnormalities play a crucial role in many tumors, including glioma. RNA methylation occurs as an epigenetic modification similar to DNA met......

TPEN attenuates amyloid-beta(25-35)-induced neuronal damage with changes in the electrophysiological properties of voltage-gated sodium and potassium channels

期刊: MOLECULAR BRAIN, 2021; 14 (1)

To understand the role of intracellular zinc ion (Zn2+) dysregulation in mediating age-related neurodegenerative changes, particularly neurotoxicity r......

Assessing the effect of interaction between C-reactive protein and gut microbiome on the risks of anxiety and depression

期刊: MOLECULAR BRAIN, 2021; 14 (1)

Cumulative evidence shows that gut microbiome can influence brain function and behavior via the inflammatory processes. However, the role of interacti......

iTRAQ-based proteomic profiling reveals protein alterations after traumatic brain injury and supports thyroxine as a potential treatment

期刊: MOLECULAR BRAIN, 2021; 14 (1)

Traumatic brain injury (TBI) is a primary cause of disability and death across the world. Previously, RNA analysis was widely used to study the pathop......

Long-range GABAergic projections from the nucleus of the solitary tract

期刊: MOLECULAR BRAIN, 2021; 14 (1)

The nucleus of the solitary tract (NTS) plays a crucial role in integrating peripheral information regarding visceral functions. Glutamate decarboxyla......

RNA-seq co-expression network analysis reveals anxiolytic behavior of mice with Efnb2 knockout in parvalbumin plus neurons

期刊: MOLECULAR BRAIN, 2021; 14 (1)

Anxiety disorders are the most common psychiatric disorders, and the change in the activity of the prefrontal cortex (PFC) is considered as the underl......

Loss of Calretinin in L5a impairs the formation of the barrel cortex leading to abnormal whisker-mediated behaviors

期刊: MOLECULAR BRAIN, 2021; 14 (1)

The rodent whisker-barrel cortex system has been established as an ideal model for studying sensory information integration. The barrel cortex consist......

Intraperitoneal injection of lithium chloride induces lateralized activation of the insular cortex in adult mice

期刊: MOLECULAR BRAIN, 2021; 14 (1)

Insular cortex is a critical brain region that participates in the interoceptive sensations. Here, we combined the iDISCO + method and Fos immunostain......

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