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Gut-derived lipopolysaccharide promotes alcoholic hepatosteatosis and subsequent hepatocellular carcinoma by stimulating neutrophil extracellular traps through toll-like receptor 4

期刊: CLINICAL AND MOLECULAR HEPATOLOGY, 2022; 28 (3)

Background/Aims: Binge drinking leads to many disorders, including alcoholic hepatosteatosis, which is characterized by intrahepatic neutrophil infilt......

Decreased vitamin D-binding protein level portends poor outcome in acute-on-chronic liver failure caused by hepatitis B virus

期刊: CLINICAL AND MOLECULAR HEPATOLOGY, 2022; 28 (4)

Background/Aims: Acute- on-chronic liver failure (ACLF) is a catastrophic illness. Few studies investigated the prognostic value of vitamin D-binding ......

RNA interference as a novel treatment strategy for chronic hepatitis B infection

期刊: CLINICAL AND MOLECULAR HEPATOLOGY, 2022; 28 (3)

Chronic hepatitis B (CHB) is a major cause of liver-related morbidity and mortality. Functional cure of CHB, defined as sustainable hepatitis B surfac......

Protective association of Klotho rs495392 gene polymorphism against hepatic steatosis in non-alcoholic fatty liver disease patients

期刊: CLINICAL AND MOLECULAR HEPATOLOGY, 2022; 28 (2)

Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic dysfunction. Among the multiple factors, genetic varia......

Old and new classes of glucose-lowering agents as treatments for non-alcoholic fatty liver disease: A narrative review

期刊: CLINICAL AND MOLECULAR HEPATOLOGY, 2022; 28 (4)

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease with a global prevalence of about 55% in people with type 2......

COVID-19 vaccine immunogenicity among chronic liver disease patients and liver transplant recipients: A meta-analysis

期刊: CLINICAL AND MOLECULAR HEPATOLOGY, 2022; 28 (4)

Background/Aims: Data of coronavirus disease 2019 (COVID-19) vaccine immunogenicity among chronic liver disease (CLD) and liver transplant (LT) patien......

Effect of moderate-to-severe hepatic steatosis on neutralising antibody response among BNT162b2 and CoronaVac recipients

期刊: CLINICAL AND MOLECULAR HEPATOLOGY, 2022; 28 (3)

Background/Aims: Studies of hepatic steatosis (HS) effect on COVID-19 vaccine immunogenicity are lacking. We aimed to compare immunogenicity of BNT162......

U-shaped relationship between urea level and hepatic decompensation in chronic liver diseases

期刊: CLINICAL AND MOLECULAR HEPATOLOGY, 2022; 28 (1)

Background/Aims: We aimed to determine the association between blood urea level and incident cirrhosis, hepatic decompensation, and hepatocellular car......

Serum fibrosis index-based risk score predicts hepato-cellular carcinoma in untreated patients with chronic hepatitis B

期刊: CLINICAL AND MOLECULAR HEPATOLOGY, 2021; 27 (3)

Background/Aims: Serum fibrosis scores comprised of common laboratory tests have high utility to assess severity of liver fibrosis. We aimed to derive......

Serum lipocalin-2 is a potential biomarker for the clinical diagnosis of nonalcoholic steatohepatitis

期刊: CLINICAL AND MOLECULAR HEPATOLOGY, 2021; 27 (2)

Background/Aims: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steato......

Long non-coding RNAs in liver diseases: Focusing on nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease

期刊: CLINICAL AND MOLECULAR HEPATOLOGY, 2020; 26 (4)

Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They......

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