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Noncoding mutation in RPGRIP1 contributes to inherited retinal degenerations

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: Despite the extensive use of next-generation sequencing (NGS) technology to identify disease-causing genomic variations, a major gap in our u......

Piezo2 downregulation via the Cre-lox system affects aqueous humor dynamics in mice

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: Proper aqueous humor (AH) dynamics is crucial for maintaining the intraocular pressure (IOP) in the eye. This study aims to investigate the f......

Synaptic changes and the response of microglia in a light-induced photoreceptor degeneration model

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: To explore synaptic changes and the response of microglia in a light-induced photoreceptor degeneration model. Methods: Sprague-Dawley rats w......

Neuroprotective effect of minocycline on rat retinal ischemia-reperfusion injury

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: To examine the neuroprotective effect of minocycline on retinal ischemia-reperfusion (IR) injury in rats and investigate its possible mechani......

Enhanced migration of engrafted retinal progenitor cells into the host retina via disruption of glial barriers

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: Migration and integration remain critical challenges for stem cell replacement therapy. Glial barriers play an important role in preventing c......

Chemerin promotes microangiopathy in diabetic retinopathy via activation of ChemR23 in rat primary microvascular endothelial cells

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: The correlation between chemerin and diabetic retinopathy (DR) has been demonstrated previously. We aimed to investigate the potential inflam......

Transient reduction in the retinal microvascular network following implantation surgery of implantable collamer lens: An OCT angiography study

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: To evaluate changes in the retinal microvascular network after posterior chamber phakic implantable collamer lens (ICL) surgery using optical......

Heterozygous GJA1 variants with ocular phenotype: Missense in domain but truncation out of domain

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: Oculodentodigital dysplasia (ODDD) is a group disorder caused by GJA1 variants, of which glaucoma leading to blindness is a frequent complica......

Functional analysis of deleterious EPHA2 SNPs in lens epithelial cells

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: Ephrin (Eph) receptor A2 (EPHA2) polymorphism has been associated with age-related cataract (ARC) in different populations worldwide, but the......

Clinical characterization and the improved molecular diagnosis of autosomal dominant cone-rod dystrophy in patients with SCA7

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: To evaluate the retinal phenotype and genetic features of Chinese patients with spinocerebellar ataxia type 7 (SCA7). Methods: Detailed ophth......

Identification of a novel mutation in KIF11 with functional analysis in a cohort of 516 familial patients with exudative vitreoretinopathy

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: To identify a novel mutation in KIM with clinical and functional analysis among 516 familial patients with exudative vitreoretinopathy (FEVR)......

Differences in activation of intracellular signaling in primary human retinal endothelial cells between isoforms of VEGFA 165

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: There are reports that a b-isoform of vascular endothelial growth factor-A 165 (VEGFA(165)b) is predominant in normal human vitreous, switchi......

Comparative proteome analysis of form-deprivation myopia in sclera with iTRAQ-based quantitative proteomics

期刊: MOLECULAR VISION, 2021; 27 ()

Objective: Scleral remodeling plays a key role in axial elongation in myopia. The aim of the present study was to identify the proteomics changes and ......

Whole mitochondrial genome analysis in Chinese patients with keratoconus

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: Keratoconus (KC) is a corneal disorder characterized by corneal ectasia, progressive corneal thinning, and conical protrusion. This study aim......

Spectrum of germline mutations in RB1 in Chinese patients with retinoblastoma: Application of targeted next-generation sequencing

期刊: MOLECULAR VISION, 2021; 27 ()

Purpose: Retinoblastoma (RB) is a pediatric ocular malignancy due to biallelic inactivation of the RB1 gene. Genetic testing is critically important f......

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