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XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA

期刊: GENES TO CELLS, 2022; 27 (5)

Base excision repair (BER) removes damaged bases by generating single-strand breaks (SSBs), gap-filling by DNA polymerase beta (POL beta), and reseali......

JIF:1.725

miR-29c-3p regulates TET2 expression and inhibits autophagy process in Parkinson's disease models

期刊: GENES TO CELLS, 2021; 26 (9)

Autophagy in dopamine (DA) neurons is concerned to be associated with Parkinson's disease (PD), but the detailed mechanism remains unknown. Herein, we......

TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands

期刊: GENES TO CELLS, 2021; 26 (9)

There are currently no treatments for salivary gland diseases, making it vital to understand signaling mechanisms operating in acinar and ductal cells......

Identification of CD56(dim) subpopulation marked with high expression of GZMB/PRF1/PI-9 in CD56(+) interferon-alpha-induced dendritic cells

期刊: GENES TO CELLS, ; ()

As the sentinels of innate and adaptive immune system, dendritic cells (DCs) have been considered to hold a great promise for medical application. Amo......

Homeodomain protein DLX4 facilitates nasopharyngeal carcinoma progression via up-regulation of YB-1

期刊: GENES TO CELLS, 2020; 25 (7)

Nasopharyngeal carcinoma (NPC) is a malignant tumor in nasopharynx tissues and lacks effective treatment strategies. Dysregulation of distal-less home......

Bombyx mori monocarboxylate transporter 9 (BmMCT9) is involved in the transport of uric acid in silkworm integument

期刊: GENES TO CELLS, 2020; 25 (1)

In Bombyx mori, there are more than 30 mutant strains exhibiting the translucent larval skin resulting from a decrease in the uric acid content in epi......

miR-29c-3p inhibits microglial NLRP3 inflammasome activation by targeting NFAT5 in Parkinson's disease

期刊: GENES TO CELLS, 2020; 25 (6)

Microglial inflammation is identified as a key process associated with Parkinson's disease (PD) pathogenesis. Our previous study showed that miR-29c-3......

Lipoprotein receptor-related protein 6 is required to maintain intercalated disk integrity

期刊: GENES TO CELLS, 0; ()

The intercalated disk (ID), a highly organized adhesion structure connecting neighboring cardiomyocytes, fulfills mechanical and electrical signaling ......

Super-resolution imaging reveals changes in Escherichia coli SSB localization in response to DNA damage

期刊: GENES TO CELLS, 0; ()

The E. coli single-stranded DNA-binding protein (SSB) is essential to viability. It plays key roles in DNA metabolism where it binds to nascent single......

Transcriptome analysis shows ambiguous phenotypes of murine primitive endoderm-related stem cell lines

期刊: GENES TO CELLS, 2019; 24 (4)

Primitive endoderm (PrE)-related cell lines (XEN, pXEN and nEnd cells) show key features of the PrE. By transcriptome analysis, we show: (a) Compared ......

JIF:1.92

I-131 reinforces antitumor activity of metuximab by reversing epithelial-mesenchymal transition via VEGFR-2 signaling in hepatocellular carcinoma

期刊: GENES TO CELLS, 2018; 23 (1)

CD147 is highly expressed in hepatocellular carcinoma (HCC) and associated with the invasion and metastasis of HCC. The efficacy of I-131-metuximab (I......

JIF:1.92

Drosophila flies high over the Asia-Pacific: Report on the Fourth Asia-Pacific Drosophila Research Conference

期刊: GENES TO CELLS, 2018; 23 (7)

The Fourth Asia-Pacific Drosophila Research Conference (APDRC4) was held at the convention center of Osaka University, Osaka, Japan, on May 8-11, 2017......

JIF:1.92

eIF2 kinases PERK and GCN2 act on FOXO to potentiate FOXO activity

期刊: GENES TO CELLS, 2018; 23 (9)

PERK and GCN2 are eIF2 kinases known to mediate the effects of ER stress and respond to an array of diverse stress stimuli. Previously, we reported th......

JIF:1.92

Opposing roles of IgM and IgD in BCR-induced B-cell survival

期刊: GENES TO CELLS, 2018; 23 (10)

The B-cell receptor (BCR) transmits a tonic survival signal in the absence of antigen stimulation and an antigen-triggered survival signal. Mature B c......

JIF:1.92

Cdk1-interacting protein Cip1 is regulated by the Sphase checkpoint in response to genotoxic stress

期刊: GENES TO CELLS, 2017; 22 (10)

In eukaryotic cells, a surveillance mechanism, the S phase checkpoint, detects and responds to insults that challenge chromosomal replication, arresti......

JIF:2.05

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