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Chemopreventive effect of galangin against benzo(a)pyrene-induced stomach tumorigenesis through modulating aryl hydrocarbon receptor in Swiss albino mice

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2021; 40 (9)

The present study was aimed to evaluate the chemopreventive potential of galangin against benzo(a)pyrene (BaP)-induced stomach carcinogenesis in Swiss......

The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2021; 40 (7)

Methotrexate (MTX) is frequently used drug in treatment of cancer and autoimmune diseases. Unfortunately, MTX has many side effects including the hepa......

Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3 beta modulation

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, 2021; 40 (8)

Paraoxonase 2 (PON2) is a powerful antioxidant that mediates cell survival under oxidative stress; however, its protection neurons against cerebral is......

CTRP3 protects hippocampal neurons from oxygen-glucose deprivation-induced injury through the AMPK/Nrf2/ARE pathway

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

Objective: C1q/TNF-related protein 3 (CTRP3), a member of CTRP family, has been found to have neuroprotective effect. In the current study, we investi......

Role of inhibiting Chk1-p53 pathway in hepatotoxicity caused by chronic arsenic exposure from coal-burning

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

Arsenic is a naturally occurring environmental toxicant, chronic exposure to arsenic can cause multiorgan damage, except for typical skin lesions, liv......

Nrf2 mediates the neuroprotective effect of isoflurane preconditioning in cortical neuron injury induced by oxygen-glucose deprivation

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

Objective: To investigate how nuclear factor-E2-related factor 2 (Nrf2) involved in the protective effect of isoflurane (Iso) preconditioning in oxyge......

Alendronate promotes the gene expression of extracellular matrix mediated by SP-1/SOX-9

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

Background and purpose: Osteoarthritis (OA) is a disease with significant degenerative changes of articular cartilage, which is reported to be closely......

ILF3-AS1 promotes cell proliferation and inhibits cell apoptosis of breast cancer by binding with miR-4429 to upregulate RAB14

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

As one of the leading causes of cancer-related deaths among women, breast cancer accounts for a 30% increase of incidence worldwide since 1970s. Recen......

Effect of fenofibrate on proliferation of SMMC-7721 cells via regulating cell cycle

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

Liver cancer is a malignant cancer with great harmfulness. Fenofibrate is a peroxisome proliferation activated receptor (PPAR alpha) agonist widely us......

MicroRNA-26b-5p alleviates cerebral ischemia-reperfusion injury in rats via inhibiting the N-myc/PTEN axis by downregulating KLF10 expression

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

MicroRNAs plays important role in cerebral ischemia-reperfusion (CIR). However, the role of miR-26b-5p in CIR injury remains unclear. PC12 cells were ......

MiR-30a-5p inhibits proliferation, migration and invasion of nasopharyngeal carcinoma cells by targeting NUCB2

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

Background: Nasopharyngeal carcinoma (NPC) is a malignant head and neck tumor arising in the nasopharynx. MicroRNAs (miRNAs) are elucidated to exert t......

N-myc downstream regulated gene 2 ameliorates myocardial remodeling and cardiac function in heart failure rats

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

This study aims to explore the effect of NDRG2 (N-myc downstream regulated gene 2)-mediated Transforming growth factor-beta 1 (TGF-beta 1)/ Sma- and M......

Tectorigenin attenuates the OGD/R-induced HT-22 cell damage through regulation of the PI3K/AKT and the PPAR gamma/NF-kappa B pathways

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

Tectorigenin (TEC) is an effective compound that derived from many plants, such as Iris unguicularis, Belamcanda chinensis and Pueraria thunbergiana B......

Prognosis of patients in prolonged coma after severe carbon monoxide poisoning

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

Background: Late recovery in patients following prolonged coma from carbon monoxide poisoning have been reported, but the probability is unclear. The ......

Methylphenidate exerts neuroprotective effects through the AMPK signaling pathway

期刊: HUMAN & EXPERIMENTAL TOXICOLOGY, ; ()

Purpose: Cerebral ischemia is the main cause of permanent adult disabilities worldwide. This study investigated the reparative effects and potential m......

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