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Tolvaptan in Pediatric Autosomal Dominant Polycystic Kidney Disease: From Here to Where?

期刊: KIDNEY DISEASES, 2021; 7 (5)

Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, accounting for approximately 5% of all ......

Mechanisms of Scarring in Focal Segmental Glomerulosclerosis

期刊: KIDNEY DISEASES, 2021; 7 (5)

Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern characterized by focal glomerular scarring, which often progresses to sy......

Effect of Marital Status on Depression and Mortality among Patients with Chronic Kidney Disease from National Health and Nutrition Examination Survey 2005-2014

期刊: KIDNEY DISEASES, 2021; 7 (5)

Background: The relationship between marital status and CKD is rarely studied. We aimed to explore the effect of marital status on the depression and ......

Tackling Dialysis Burden around the World: A Global Challenge

期刊: KIDNEY DISEASES, 2021; 7 (3)

CKD is a global problem that causes significant burden to the healthcare system and the economy in addition to its impact on morbidity and mortality o......

Lysosome Depletion-Triggered Autophagy Impairment in Progressive Kidney Injury

期刊: KIDNEY DISEASES, 2021; 7 (4)

Background: Macroautophagy (autophagy) is a cellular recycling process involving the destruction of damaged organelles and proteins in intracellular l......

The Role of CXCL12 in Kidney Diseases: A Friend or Foe?

期刊: KIDNEY DISEASES, 2021; 7 (3)

Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of lo......

Living Well with Kidney Disease by Patient and Care-Partner Empowerment: Kidney Health for Everyone Everywhere

期刊: KIDNEY DISEASES, 2021; 7 (4)

Living with chronic kidney disease (CKD) is associated with hardships for patients and their care-partners. Empowering patients and their care-partner......

Lower Serum Irisin Levels Are Associated with Increased Abdominal Aortic Calcification in Peritoneal Dialysis Patients

期刊: KIDNEY DISEASES, 2021; 7 (3)

Introduction: Vascular calcification (VC), with the mechanisms remaining unclear, is closely related with dialysis patients' cardiovascular mortality ......

Hydroxychloroquine Inhibits Cardiac Conduction in Aged Patients with Nonmalaria Diseases

期刊: KIDNEY DISEASES, 2021; 7 (5)

Background: The COVID-19 pandemic has brought increased focus on hydroxychloroquine (HCQ), as doctors, the medical community, and policymakers around ......

Studying Kidney Diseases at the Single-Cell Level

期刊: KIDNEY DISEASES, 2021; 7 (5)

Background: The kidney is a highly complex organ that performs diverse functions that are essential for health. Kidney disease occurs when the kidneys......

Nicotinamide Supplementation Attenuates Renal Interstitial Fibrosis via Boosting the Activity of Sirtuins

期刊: KIDNEY DISEASES, ; ()

Background: Progressive tubulointerstitial fibrosis (TIF) is the final common pathway leading to ESRD. There is an urgent need to develop effective ap......

Smad3-Targeted Therapy Protects against Cisplatin-Induced AKI by Attenuating Programmed Cell Death and Inflammation via a NOX4-Dependent Mechanism

期刊: KIDNEY DISEASES, ; ()

Background: Transforming growth factor-beta (TGF-beta)/Smad signaling is the central mediator in renal fibrosis, yet its functional role in acute kidn......

Fibroblast Growth Factor 21 Predicts and Promotes Vascular Calcification in Haemodialysis Patients

期刊: KIDNEY DISEASES, ; ()

Background: Cardiovascular disease (CVD) is the leading cause of death in haemodialysis (HD) patients. Vascular calcification (VC) is dramatically acc......

A Novel Standardized Method of Renal Biopsy in Mice

期刊: KIDNEY DISEASES, ; ()

Introduction: In animal models, it can be difficult to confirm therapeutic effects due to technical inconsistencies and other reasons. Although renal ......

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