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Combining C reactive protein and serum albumin to predict 90-day mortality in systemic lupus erythematosus with serious community-acquired infections

期刊: LUPUS SCIENCE & MEDICINE, 2021; 8 (1)

Objective Serious infections in SLE are common and have emerged as the major cause of death. However, effective methods to identify poor prognosis are......

Performance of the 2019 EULAR/ACR systemic lupus erythematosus classification criteria in a cohort of patients with biopsy-confirmed lupus nephritis

期刊: LUPUS SCIENCE & MEDICINE, 2021; 8 (1)

Objective To evaluate the performance of the European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) SLE classification criter......

Effects of metformin on disease flares in patients with systemic lupus erythematosus: post hoc analyses from two randomised trials

期刊: LUPUS SCIENCE & MEDICINE, 2020; 7 (1)

Objective To confirm that metformin prevents flares in patients with SLE with low disease activity, we performed a post hoc analysis combining our pre......

Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE

期刊: LUPUS SCIENCE & MEDICINE, 2022; 9 (1)

Objective T cells display significant phenotypical changes and play multiple roles in promoting the immune response in SLE. The frequencies of T cell ......

Risk factors of flare in patients with systemic lupus erythematosus after glucocorticoids withdrawal. A systematic review and meta-analysis

期刊: LUPUS SCIENCE & MEDICINE, 2022; 9 (1)

Objective Glucocorticoids (GC) withdrawal is part of the targets in current recommendations for SLE, but relapse is the most worrying issue. We aimed ......

Predictors of refractory risk in systemic lupus erythematosus-related thrombocytopenia: a dual-centre retrospective study

期刊: LUPUS SCIENCE & MEDICINE, 2022; 9 (1)

Objectives Based on clinical and laboratory indicators, this study aimed to establish a multiparametric nomogram to assess the risk of refractory case......

Utility of the ACR-1997, SLICC-2012 and EULAR/ACR-2019 classification criteria for systemic lupus erythematosus: a single-centre retrospective study

期刊: LUPUS SCIENCE & MEDICINE, 2022; 9 (1)

Background and aims Several different versions of classification criteria, including the American College of Rheumatology (ACR)-1997, Systemic Lupus I......

Low-dose belimumab for patients with systemic lupus erythematosus at low disease activity: protocol for a multicentre, randomised, double-blind, placebo-controlled clinical trial

期刊: LUPUS SCIENCE & MEDICINE, 2022; 9 (1)

Introduction SLE is a chronic inflammatory systemic autoimmune disease with relapsing-remitting pattern. B-lymphocyte stimulator was involved in the p......

Association between systemic lupus erythematosus and disruption of gut microbiota: a meta-analysis

期刊: LUPUS SCIENCE & MEDICINE, 2022; 9 (1)

Objective Recent studies reported that SLE is characterised by altered interactions between the microbiome and immune system. We performed a meta-anal......

Sirolimus versus tacrolimus for systemic lupus erythematosus treatment: results from a real-world CSTAR cohort study

期刊: LUPUS SCIENCE & MEDICINE, 2022; 9 (1)

Objective The effectiveness and safety of sirolimus for SLE treatment have been shown in some uncontrolled studies. However, a comparison of sirolimus......

Flare rates and factors determining flare occurrence in patients with systemic lupus erythematosus who achieved low disease activity or remission: results from a prospective cohort study

期刊: LUPUS SCIENCE & MEDICINE, 2022; 9 (1)

Objective To investigate the frequency and determinants of flare in Chinese patients with lupus, focusing on the effect of glucocorticoid (GC) taperin......

Peripheral blood T-cell subset and its clinical significance in lupus nephritis patients

期刊: LUPUS SCIENCE & MEDICINE, 2022; 9 (1)

Objectives Lupus nephritis (LN) is a common and severe manifestation of SLE. Memory T (TM) cells have been implicated in the pathogenesis of SLE. This......

Major infections in newly diagnosed systemic lupus erythematosus: an inception cohort study

期刊: LUPUS SCIENCE & MEDICINE, 2022; 9 (1)

Objective To evaluate the risk of major infections and the relationship between major infections and mortality in patients with newly diagnosed SLE. M......

Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway

期刊: LUPUS SCIENCE & MEDICINE, 2022; 9 (1)

Objective Lupus nephritis (LN) is a major complication and cause of death among patients with SLE. This research used in vivo and in vitro experiments......

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