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Hyperphosphatemia rather than hypophosphatemia indicates a poor prognosis in patients with sepsis

期刊: CLINICAL BIOCHEMISTRY, 2021; 91 ()

Background: Sepsis is the leading cause of hospitalization and death in the intensive care unit. It is vital to identify high-risk patients with poor ......

Clinical laboratory characteristics of patients with obstructive jaundice accompanied by dyslipidemia

期刊: CLINICAL BIOCHEMISTRY, 2021; 94 ()

Background: Abnormal lipid metabolism manifests as hypercholesterolemia in patients with obstructive jaundice due to lipoprotein X (LpX). Our aim was ......

Application of a six sigma model to the evaluation of the analytical performance of serum enzyme assays and the design of a quality control strategy for these assays: A multicentre study

期刊: CLINICAL BIOCHEMISTRY, 2021; 91 ()

Background: Six medical testing laboratories at six different sites in China participated in this study. We applied a six sigma model for (a) the eval......

Effect of sample size and the traditional parametric, nonparametric, and robust methods on the establishment of reference intervals: Evidence from real world data

期刊: CLINICAL BIOCHEMISTRY, 2021; 92 ()

Sample size and statistical methods are critical for establishing reference intervals (RIs) but they tend to be overlooked. In this study, we used R (......

Chemotherapy-associated clonal hematopoiesis mutations should be taken seriously in plasma cell-free DNA KRAS/NRAS/BRAF genotyping for metastatic colorectal cancer

期刊: CLINICAL BIOCHEMISTRY, 2021; 92 ()

Background: Genotyping of plasma cell-free DNA (cfDNA) is an increasingly important method to assess the tumor mutation status in colorectal cancer (C......

Rapid detection of twenty-nine common Chinese glucose-6-phosphate dehydrogenase variants using a matrix-assisted laser desorption/ionization-time of flight mass spectrometry assay on dried blood spots

期刊: CLINICAL BIOCHEMISTRY, 2021; 94 ()

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited disease. Current neonatal screening methods for G6PD defi......

Reference intervals for preterm thyroid function during the fifth to seventh day of life

期刊: CLINICAL BIOCHEMISTRY, 2021; 95 ()

Background: Due to the lack of reference intervals for serum free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) i......

Preparation, stability and commutability of candidate reference materials for lactate dehydrogenase (LDH)

期刊: CLINICAL BIOCHEMISTRY, 2021; 91 ()

Background: Lactate dehydrogenase (LDH) is a key enzyme that functions as a marker of cell damage. Its activity can be measured by a variety of labora......

Roles of matrix metalloproteinase-7 (MMP-7) in cancer

期刊: CLINICAL BIOCHEMISTRY, 2021; 92 ()

Matrix metalloproteinase-7 (MMP-7) is a small proteolytic enzyme that secretes zinc and calcium endopeptidases. It can degrade a variety of extracellu......

The clinical role of combined serum C1q and hsCRP in predicting coronary artery disease

期刊: CLINICAL BIOCHEMISTRY, 2021; 93 ()

Objective: C1q has been shown to be associated with coronary heart disease (CAD) and can co-deposit with Creactive protein (CRP) in atherosclerotic pl......

Detection of glucosylsphingosine in dried blood spots for diagnosis of Gaucher disease by LC-MS/MS

期刊: CLINICAL BIOCHEMISTRY, 2021; 87 ()

Introduction: Gaucher disease (GD) is caused by a deficiency of beta-glucosidase (GCase), leading to accumulation of glucosylceramide (GlcC) and gluco......

A 3-min UPLC-MS/MS method for the simultaneous determination of plasma catecholamines and their metabolites: Method verification and diagnostic efficiency

期刊: CLINICAL BIOCHEMISTRY, 2021; 87 ()

Objective: To verify a rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the quantification......

Sfrp5/Wnt5a and leptin/adiponectin levels in the serum and the periarterial adipose tissue of patients with peripheral arterial occlusive disease

期刊: CLINICAL BIOCHEMISTRY, 2021; 87 ()

Background: Leptin, adiponectin, secreted frizzled-related protein 5 (Sfrp5) and wingless-type family member 5a (Wnt5a) are novel adipokines that are ......

Commutability of possible external quality assessment materials for progesterone measurement

期刊: CLINICAL BIOCHEMISTRY, 2021; 87 ()

Background: The commutability of control materials used for external quality assessment (EQA) programs is of great importance. Evaluating the commutab......

The potential value of Copeptin and Pentraxin3 for evaluating the severity of coronary stenosis in patients with coronary artery disease

期刊: CLINICAL BIOCHEMISTRY, 2021; 87 ()

Introduction: Coronary artery disease (CAD) is an ischemic heart disease due to the narrowing of the coronary arteries resulting from atherosclerosis.......

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