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The functional role of inherited CDKN2A variants in childhood acute lymphoblastic leukemia

期刊: PHARMACOGENETICS AND GENOMICS, 2022; 32 (2)

Objective Genetic alterations in CDKN2A tumor suppressor gene on chromosome 9p21 confer a predisposition to childhood acute lymphoblastic leukemia (AL......

JIF:1.549

Impact of cytochrome P450 2C19 polymorphisms on the clinical efficacy and safety of voriconazole: an update systematic review and meta-analysis

期刊: PHARMACOGENETICS AND GENOMICS, 2022; 32 (7)

Objective To assess the impact of cytochrome P450 (CYP) 2C19 polymorphisms on the clinical efficacy and safety of voriconazole. Methods We systematica......

JIF:1.549

Identification of potential druggable targets of cell cycle with small-molecule inhibitors in oral squamous cell carcinoma

期刊: PHARMACOGENETICS AND GENOMICS, 2022; 32 (4)

Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors worldwide and there are few crucial regulators and druggable targets fo......

JIF:1.549

Investigation of pharmacologic interactions between omeprazole and tacrolimus in a membranous nephropathy patient with CYP3A5 nonexpresser: a case report

期刊: PHARMACOGENETICS AND GENOMICS, 2022; 32 (7)

Tacrolimus has been widely used in membranous nephropathy in recent years. The drug interactions of the coadministration of tacrolimus with omeprazole......

JIF:1.549

Pharmacogenetic study of methadone treatment for heroin addiction: associations between drug-metabolizing gene polymorphisms and treatment efficacy

期刊: PHARMACOGENETICS AND GENOMICS, 2022; 32 (1)

Objectives Opioid dependence is currently one of the most serious problems affecting the social norms and public health system. Methadone maintenance ......

JIF:1.549

Association of SLC22A1 rs622342 and ATM rs11212617 polymorphisms with metformin efficacy in patients with type 2 diabetes

期刊: PHARMACOGENETICS AND GENOMICS, 2022; 32 (2)

Metformin is the first-choice oral anti-hyperglycemic drug for type 2 diabetes mellitus (T2DM) patients. There are controversies about the association......

JIF:1.549

Effects of CYP2C19, CYP2C9 and CYP3A4 gene polymorphisms on plasma voriconazole levels in Chinese pediatric patients

期刊: PHARMACOGENETICS AND GENOMICS, 2022; 32 (4)

Objectives Voriconazole is the most commonly used antifungal agent in clinical application. Previous studies suggested that voriconazole was extensive......

JIF:1.549

Associations of CYP2C19 and F2R genetic polymorphisms with platelet reactivity in Chinese ischemic stroke patients receiving clopidogrel therapy

期刊: PHARMACOGENETICS AND GENOMICS, 2022; 32 (4)

Objectives Genetic variation has been considered a major contributor to the high variability in the response to dual antiplatelet therapy in patients ......

JIF:1.549

Association of anti-TNF-alpha treatment with gut microbiota of patients with ankylosing spondylitis

期刊: PHARMACOGENETICS AND GENOMICS, 2022; 32 (7)

Objective Gut dysbiosis contributes to multiple autoimmune diseases, including ankylosing spondylitis. which is commonly treated with tumor necrosis f......

JIF:1.549

Anxiety symptom remission is associated with genetic variation of PTPRZ1 among patients with major depressive disorder treated with escitalopram

期刊: PHARMACOGENETICS AND GENOMICS, 2021; 31 (8)

Objectives Genome-wide analyses of antidepressant response have suggested that genes initially associated with risk for schizophrenia may also serve a......

Influence of CMTM8 polymorphisms on lung cancer susceptibility in the Chinese Han population

期刊: PHARMACOGENETICS AND GENOMICS, 2021; 31 (4)

Background Lung cancer is the leading cause of cancer-related mortality worldwide and CMTM8 is a potential tumor suppressor gene, which is down-regula......

Association of FAM65B, AGBL4, and CUX2 genetic polymorphisms with susceptibility to antituberculosis drug-induced hepatotoxicity: validation study in a Chinese Han population

期刊: PHARMACOGENETICS AND GENOMICS, 2019; 29 (4)

Objective Antituberculosis (anti-TB) drug-induced hepatotoxicity (ATDH) is a serious adverse drug reaction, and its pathogenic mechanism has not been ......

JIF:2.69

The association between the SLCO1B1, apolipoprotein E, and CYP2C9 genes and lipid response to fluvastatin: a meta-analysis

期刊: PHARMACOGENETICS AND GENOMICS, 2018; 28 (12)

Objective The aim of this study was to determine the impact of the SLCO1B1, apolipoprotein E (ApoE), and CYP2C9 genotypes on the lipid-lowering effica......

JIF:2.69

A retrospective investigation of HLA-B*5801 in hyperuricemia patients in a Han population of China

期刊: PHARMACOGENETICS AND GENOMICS, 2018; 28 (5)

BackgroundHyperuricemia and gout have become increasingly prevalent in China. Allopurinol is an effective urate-lowering therapy, but it has severe si......

JIF:2.69

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