A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells

Xu, CX; Meng, FY; Park, KS; Storey, AJ; Gong, WD; Tsai, YH; Gibson, E; Byrum, SD; Li, DX; Edmondson, RD; Mackintosh, SG; Vedadi, M; Cai, L; Tackett, AJ; Kaniskan, HU; Jin, J; Wang, GG

Wang, GG (通讯作者),Univ N Carolina, Lineberger Comprehens Canc Ctr, Sch Med, Chapel Hill, NC 27599 USA.;Wang, GG (通讯作者),Univ N Carolina, Dept Biochem & Biophys, Sch Med, Chapel Hill, NC 27599 USA.;Kaniskan, HU; Jin, J (通讯作者),Icahn Sch Med Mt Sinai, Mt Sinai Ctr Therapeut Discovery, Dept Pharmacol Sci, Tisch Canc Inst, New York, NY 10029 USA.;Kaniskan, HU; Jin, J (通讯作者),Icahn Sch Med Mt Sinai, Mt Sinai Ctr Therapeut Discovery, Dept Oncol Sci, Tisch Canc Inst, New York, NY 10029 USA.;Wang, GG (通讯作者),

CELL CHEMICAL BIOLOGY, 2022; 29 (3): 386

Abstract

Nuclear receptor binding SET domain protein 3 (NSD3), a gene located within the 8p11-p12 amplicon frequently detected in human cancers, encodes a chro......

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