Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778

Ji, XK; Jiang, XY; Kobayashi, C; Ren, YJ; Hu, LD; Gao, Z; Kang, DW; Jia, RF; Zhang, XJ; Zhao, SJ; Watashi, K; Liu, XY; Zhan, P

Liu, XY; Zhan, P (通讯作者)，Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Key Lab Chem Biol,Minist Educ,Cheeloo Coll Med, 44 West Culture Rd, Jinan 250012, Peoples R China.;Watashi, K (通讯作者)，Natl Inst Infect Dis, Dept Virol 2, Tokyo 1638001, Japan.;Watashi, K (通讯作者)，Tokyo Univ Sci, Dept Appl Biol Sci, Noda, Chiba 2788510, Japan.;Watashi, K (通讯作者)，Natl Inst Infect Dis, Res Ctr Drug & Vaccine Dev, Tokyo 1638001, Japan.

MOLECULES, 2022; 27 (18):

Abstract

Hepatitis B virus (HBV) capsid protein (Cp) is necessary for viral replication and the maintenance of viral persistence, having become an attractive t......

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