Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Fowler, S; Brink, A; Cleary, Y; Gunther, A; Heinig, K; Husser, C; Kletzl, H; Kratochwil, N; Mueller, L; Savage, M; Stillhart, C; Tuerck, D; Ullah, M; Umehara, K; Poirier, A

Poirier, A (通讯作者)，F Hoffmann La Roche Ltd, Pharmaceut Sci Roche Pharma Res & Early Dev, Roche Innovat Ctr Basel, Grenzacherstr 124, CH-4070 Basel, Switzerland.

DRUG METABOLISM AND DISPOSITION, 2022; 50 (1): 65

Abstract

Small molecules that present complex absorption, distribution, metabolism, and elimination (ADME) properties can be challenging to investigate as pote......

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