IRF2 transcriptionally induces GSDMD expression for pyroptosis

Kayagaki, N; Lee, BL; Stowe, IB; Kornfeld, OS; O'Rourke, K; Mirrashidi, KM; Haley, B; Watanabe, C; Roose-Girma, M; Modrusan, Z; Kummerfeld, S; Reja, R; Zhang, YF; Cho, V; Andrews, TD; Morris, LX; Goodnow, CC; Bertram, EM; Dixit, VM

Kayagaki, N; Dixit, VM (reprint author), Genentech Inc, Dept Physiol Chem, San Francisco, CA 94080 USA.

SCIENCE SIGNALING, 2019; 12 (582):

Abstract

Gasdermin-D (GSDMD) is cleaved by caspase-1, caspase-4, and caspase-11 in response to canonical and noncanonical inflammasome activation. Upon cleavag......

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