Anthracyclines React with Apurinic/Apyrimidinic Sites in DNA

Bellamri, M; Terrell, JT; Brandt, K; Gruppi, F; Turesky, RJ; Rizzo, CJ

Turesky, RJ (通讯作者),Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA.;Turesky, RJ (通讯作者),Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA.;Rizzo, CJ (通讯作者),Vanderbilt Univ, Chem, Biochem, Nashville, TN 37235 USA.;Rizzo, CJ (通讯作者),Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN 37235 USA.

ACS CHEMICAL BIOLOGY, 2023; 18 (6): 1315

Abstract

The combination of doxorubicin (Adriamycin) and cyclophosphamide,referred to as AC chemotherapy, is commonly used for the clinicaltreatment of breast ......

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