First-in-human phase 1 study of margetuximab (MGAH22), an Fc-modified chimeric monoclonal antibody, in patients with HER2-positive advanced solid tumors

Bang, YJ; Giaccone, G; Im, SA; Oh, DY; Bauer, TM; Nordstrom, JL; Li, H; Chichili, GR; Moore, PA; Hong, S; Stewart, SJ; Baughman, JE; Lechleider, RJ; Burris, HA

Bang, YJ (reprint author), Seoul Natl Univ, Coll Med, Dept Internal Med, 101 Daehak Ro, Seoul 03080, South Korea.

ANNALS OF ONCOLOGY, 2017; 28 (4): 855

Abstract

Background: Margetuximab is an anti-HER2 antibody that binds with elevated affinity to both the lower and higher affinity forms of CD16A, an Fc-recept......

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