APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation

Marino, C; Perez-Corredor, P; O'Hare, M; Heuer, A; Chmielewska, N; Gordon, H; Chandrahas, AS; Gonzalez-Buendia, L; Delgado-Tirado, S; Doan, TH; Vanderleest, TE; Arevalo-Alquichire, S; Obar, RA; Ortiz-Cordero, C; Villegas, A; Sepulveda-Falla, D; Kim, LA; Lopera, F; Mahley, R; Huang, YD; Quiroz, YT; Arboleda-Velasquez, JF

Marino, C; Arboleda-Velasquez, JF (通讯作者)，Harvard Med Sch, Schepens Eye Res Inst Mass Eye & Ear, Dept Ophthalmol, 20 Staniford St, Boston, MA 02114 USA.

ALZHEIMERS & DEMENTIA, 2023; ():

Abstract

INTRODUCTION: We discovered that the APOE3 Christchurch (APOE3Ch) variant may provide resistance to Alzheimer's disease (AD). This resistance may be d......

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