SCFAs induce autophagy in intestinal epithelial cells and relieve colitis by stabilizing HIF-1 alpha

Zhou, C; Li, LZ; Li, TM; Sun, LH; Yin, JH; Guan, HD; Wang, LC; Zhu, HB; Xu, P; Fan, X; Sheng, BF; Xiao, WD; Qiu, Y; Yang, H

Qiu, Y; Yang, H (corresponding author), Army Med Univ, Xinqiao Hosp, Dept Gen Surg, Chongqing, Peoples R China.; Qiu, Y (corresponding author), Third Mil Med Univ, State Key Lab Trauma Burn & Combined Injury, Chongqing, Peoples R China.

JOURNAL OF MOLECULAR MEDICINE-JMM, 2020; 98 (8): 1189

Abstract

Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a critical regulator of barrier integrity during colonic mucosal injury. Previous works have shown t......

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