Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance

Zhou, W; Sun, W; Yung, MMH; Dai, S; Cai, YH; Chen, CW; Meng, YX; Lee, JB; Braisted, JC; Xu, YH; Southall, NT; Shinn, P; Huang, XF; Song, ZF; Chen, XL; Kai, Y; Cai, X; Li, ZZ; Hao, Q; Cheung, ANY; Ngan, HYS; Liu, SS; Barak, S; Hao, J; Dai, ZJ; Tzatsos

Zhu, WG (reprint author), George Washington Univ, Sch Med & Hlth Sci, Dept Biochem & Mol Med, Washington, DC 20037 USA.; Zhu, WG (reprint author), George Washington Univ, GW Canc Ctr, Washington, DC 20052 USA.; Zheng, W (reprint author), Natl Ctr Adv Tran

ONCOGENE, 2018; 37 (29): 3981

Abstract

Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resista......

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