Targeting NAD+ metabolism of hepatocellular carcinoma cells by lenvatinib promotes M2 macrophages reverse polarization, suppressing the HCC progression

Sun, QC; Shen, MY; Zhu, SB; Liao, YX; Zhang, DY; Sun, JY; Guo, ZQ; Wu, LY; Xiao, LS; Liu, L

Liu, L (通讯作者)，Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou 510515, Peoples R China.;Liu, L (通讯作者)，State Key Lab Organ Failure Res, Guangzhou 510515, Peoples R China.;Liu, L (通讯作者)，Guangdong Prov Key Lab Viral Hepatitis Res, Guangzhou 510515, Peoples R China.

HEPATOLOGY INTERNATIONAL, 2023; 17 (6): 1444

Abstract

BackgroundLowered nicotinamide adenine dinucleotide (NAD(+)) levels in tumor cells drive tumor hyperprogression during immunotherapy, and its restorat......

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