Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors

Plenker, D; Riedel, M; Bragelmann, J; Dammert, MA; Chauhan, R; Knowles, PP; Lorenz, C; Keul, M; Buhrmann, M; Pagel, O; Tischler, V; Scheel, AH; Schtte, D; Song, YR; Stark, J; Mrugalla, F; Alber, Y; Richters, A; Engel, J; Leenders, F; Heuckmann, JM; W

Sos, ML (reprint author), Univ Hosp Cologne, Ctr Integrated Oncol, Inst Pathol, Mol Pathol, D-50937 Cologne, Germany.; Sos, ML (reprint author), Univ Hosp Cologne, Dept Translat Genom, Ctr Integrated Oncol Cologne Bonn, Med Fac, D-50937 Cologne, Germany.

SCIENCE TRANSLATIONAL MEDICINE, 2017; 9 (394):

Abstract

Oncogenic fusion events have been identified in a broad range of tumors. Among them, RET rearrangements represent distinct and potentially druggable t......

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