TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation

Li, K; Wang, F; Yang, ZN; Zhang, TT; Yuan, YF; Zhao, CX; Yeerjiang, Z; Cui, B; Hua, F; Lv, XX; Zhang, XW; Yu, JJ; Liu, SS; Yu, JM; Shang, S; Xiao, Y; Hu, ZW

Hu, ZW (corresponding author), Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Metab Dis, Dept Endocrinol & Metab, Changsha 410011, Hunan, Peoples R China.; Hu, ZW (corresponding author), Peking Union Med Coll, Beijing 100050, Peoples R China.; Hu, ZW (corresponding author), Chinese Acad Med Sci, Immunol & Canc Pharmacol Grp, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing, Peoples R China.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

The transcription factor MYC is deregulated in almost all human cancers, especially in aggressive lymphomas, through chromosomal translocation, amplif......

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